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Statements

Subject Item
n2:RIV%2F61388955%3A_____%2F10%3A00346349%21RIV11-AV0-61388955
rdf:type
n17:Vysledek skos:Concept
dcterms:description
The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B-12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B-12 determined in blood. The changes of folates and vitamin B-12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B-12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes. The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B-12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B-12 determined in blood. The changes of folates and vitamin B-12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B-12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes.
dcterms:title
Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units
skos:prefLabel
Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units
skos:notation
RIV/61388955:_____/10:00346349!RIV11-AV0-61388955
n3:aktivita
n8:P n8:Z
n3:aktivity
P(IAA400400806), Z(AV0Z40400503), Z(MSM0021620864)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n4:6104282 n4:6505996
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
291078
n3:idVysledku
RIV/61388955:_____/10:00346349
n3:jazykVysledku
n16:eng
n3:klicovaSlova
creatine; creatinine; folates; homocysteine
n3:klicoveSlovo
n13:folates n13:homocysteine n13:creatine n13:creatinine
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[C7EC7D1B913C]
n3:nazevZdroje
Physiological Research
n3:obor
n18:CF
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n12:IAA400400806
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
59
n3:tvurceVysledku
Pelclová, D. Navrátil, Tomáš Kohlíková, E. Heyrovský, Michael Petr, M. Přistoupilová, K.
n3:wos
000280363700016
n3:zamer
n11:MSM0021620864 n11:AV0Z40400503
s:issn
0862-8408
s:numberOfPages
12