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Statements

Subject Item
n2:RIV%2F61388955%3A_____%2F10%3A00335375%21RIV11-GA0-61388955
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN NO2 + e right arrow over left arrow ETN NO2 was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined. Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN NO2 + e right arrow over left arrow ETN NO2 was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined.
dcterms:title
Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water
skos:prefLabel
Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water
skos:notation
RIV/61388955:_____/10:00335375!RIV11-GA0-61388955
n3:aktivita
n12:Z n12:P
n3:aktivity
P(GP203/09/P502), Z(AV0Z40400503)
n3:cisloPeriodika
2
n3:dodaniDat
n5:2011
n3:domaciTvurceVysledku
n4:3021793 n4:6128440 n4:5218195 n4:3906825 n4:2834057 n4:8862842
n3:druhVysledku
n15:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
296690
n3:idVysledku
RIV/61388955:_____/10:00335375
n3:jazykVysledku
n17:eng
n3:klicovaSlova
etanidazole; radiosensitizer; electron transfer; voltammetry
n3:klicoveSlovo
n13:voltammetry n13:electron%20transfer n13:radiosensitizer n13:etanidazole
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[CBF79F49E822]
n3:nazevZdroje
Bioelectrochemistry
n3:obor
n10:CG
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:projekt
n14:GP203%2F09%2FP502
n3:rokUplatneniVysledku
n5:2010
n3:svazekPeriodika
78
n3:tvurceVysledku
Híveš, J. Kolivoška, Viliam Gál, Miroslav Bulíčková, Jana Pospíšil, Lubomír Hromadová, Magdaléna Sokolová, Romana
n3:wos
000277218900004
n3:zamer
n16:AV0Z40400503
s:issn
1567-5394
s:numberOfPages
6