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Statements

Subject Item
n2:RIV%2F61383082%3A_____%2F10%3A0005%21RIV11-MO0-61383082
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Increased circulating adhesion molecules in patients with obesity play an important role in the development of endothelial dysfunction/atherosclerosis. The aim of this study was to assess the contribution of various fat depots to adhesion molecules production in obesity. 12 women with first and second degree of obesity, 13 women with third degree of obesity and 14 lean age-matched women were included into study. Circulating levels of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin were measured by Luminex kits. mRNA expression of ICAM-1, VCAM-1, E-selectin, monocyte chemoattractant protein-1 (MCP-1), and CD68 in subcutaneous (SAT) and visceral adipose tissue (VAT) was measured by RT-PCR; ICAM-1 and VCAM-1 protein levels by Luminex kits, normalized to protein content. Obesity increased ICAM-1 and VCAM-1 mRNA expression and protein levels and CD68 mRNA expression in VAT. Expression of Eselectin and MCP-1 did not significantly differ between groups. Increased circulating adhesion molecules in patients with obesity play an important role in the development of endothelial dysfunction/atherosclerosis. The aim of this study was to assess the contribution of various fat depots to adhesion molecules production in obesity. 12 women with first and second degree of obesity, 13 women with third degree of obesity and 14 lean age-matched women were included into study. Circulating levels of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin were measured by Luminex kits. mRNA expression of ICAM-1, VCAM-1, E-selectin, monocyte chemoattractant protein-1 (MCP-1), and CD68 in subcutaneous (SAT) and visceral adipose tissue (VAT) was measured by RT-PCR; ICAM-1 and VCAM-1 protein levels by Luminex kits, normalized to protein content. Obesity increased ICAM-1 and VCAM-1 mRNA expression and protein levels and CD68 mRNA expression in VAT. Expression of Eselectin and MCP-1 did not significantly differ between groups.
dcterms:title
The Influence of Obesity and Different Fat Depots on Adipose Tissue Gene Expression and Protein Levels of Cell Adhesion Molecules The Influence of Obesity and Different Fat Depots on Adipose Tissue Gene Expression and Protein Levels of Cell Adhesion Molecules
skos:prefLabel
The Influence of Obesity and Different Fat Depots on Adipose Tissue Gene Expression and Protein Levels of Cell Adhesion Molecules The Influence of Obesity and Different Fat Depots on Adipose Tissue Gene Expression and Protein Levels of Cell Adhesion Molecules
skos:notation
RIV/61383082:_____/10:0005!RIV11-MO0-61383082
n3:aktivita
n4:I n4:P n4:V
n3:aktivity
I, P(NR8302), V
n3:cisloPeriodika
1
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n12:3295850
n3:druhVysledku
n17:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
263728
n3:idVysledku
RIV/61383082:_____/10:0005
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Adhesion molecules; Atherosclerosis; Obesity; Adipose tissue; Gene expression
n3:klicoveSlovo
n8:Gene%20expression n8:Adipose%20tissue n8:Adhesion%20molecules n8:Atherosclerosis n8:Obesity
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[781AA2DB39A8]
n3:nazevZdroje
Physiological Research
n3:obor
n13:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n15:NR8302
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
59
n3:tvurceVysledku
Bošanská, L. Kasalický, Mojmír
s:issn
0862-8408
s:numberOfPages
10