This HTML5 document contains 47 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n14http://localhost/temp/predkladatel/
n19http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n11http://linked.opendata.cz/resource/domain/vavai/projekt/
n9http://linked.opendata.cz/resource/domain/vavai/subjekt/
n3http://linked.opendata.cz/ontology/domain/vavai/
n7http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/
skoshttp://www.w3.org/2004/02/skos/core#
n10http://bibframe.org/vocab/
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F60461373%3A22810%2F11%3A43892735%21RIV12-MSM-22810___/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n6http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n20http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n21http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n8http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F60461373%3A22810%2F11%3A43892735%21RIV12-MSM-22810___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
While direct Sonogashira coupling of 6-halopurines with methyl propiolate and with propargyl aldehyde was not successful, the corresponding orthoester and propargyl aldehyde diethylacetal reacted smoothly. Such prepared orthoester was then converted to the desired methylester by methanolysis, the acetal was too stable to be hydrolyzed. The obtained 6-ethynylpurines, bearing orthoester, acetal, methoxycarbonyl and for comparison also the phenyl substituent on the ethynyl group, were subjected to the cycloaddition reaction with cyclopentadiene, diazomethane and phenylazide. Electron deficient alkynylpurines were considerably more reactive in this reaction compared to the not activated phenylethynyl derivative. The prepared alkynylpurines exhibited medium cytostatic activity (IC50 = 2.6-15 mýM), while the cycloadducts were inactive. While direct Sonogashira coupling of 6-halopurines with methyl propiolate and with propargyl aldehyde was not successful, the corresponding orthoester and propargyl aldehyde diethylacetal reacted smoothly. Such prepared orthoester was then converted to the desired methylester by methanolysis, the acetal was too stable to be hydrolyzed. The obtained 6-ethynylpurines, bearing orthoester, acetal, methoxycarbonyl and for comparison also the phenyl substituent on the ethynyl group, were subjected to the cycloaddition reaction with cyclopentadiene, diazomethane and phenylazide. Electron deficient alkynylpurines were considerably more reactive in this reaction compared to the not activated phenylethynyl derivative. The prepared alkynylpurines exhibited medium cytostatic activity (IC50 = 2.6-15 mýM), while the cycloadducts were inactive.
dcterms:title
6-Alkynylpurines Bearing Electronacceptor Substituents: Preparation, Reactivity in Cycloaddition Reactions and Cytostatic Activity 6-Alkynylpurines Bearing Electronacceptor Substituents: Preparation, Reactivity in Cycloaddition Reactions and Cytostatic Activity
skos:prefLabel
6-Alkynylpurines Bearing Electronacceptor Substituents: Preparation, Reactivity in Cycloaddition Reactions and Cytostatic Activity 6-Alkynylpurines Bearing Electronacceptor Substituents: Preparation, Reactivity in Cycloaddition Reactions and Cytostatic Activity
skos:notation
RIV/60461373:22810/11:43892735!RIV12-MSM-22810___
n3:predkladatel
n9:orjk%3A22810
n5:aktivita
n17:I n17:P n17:Z
n5:aktivity
I, P(GA203/09/1552), P(LC06070), Z(AV0Z40550506)
n5:cisloPeriodika
12
n5:dodaniDat
n8:2012
n5:domaciTvurceVysledku
n19:7241852
n5:druhVysledku
n16:J
n5:duvernostUdaju
n20:S
n5:entitaPredkladatele
n18:predkladatel
n5:idSjednocenehoVysledku
244239
n5:idVysledku
RIV/60461373:22810/11:43892735
n5:jazykVysledku
n12:eng
n5:klicovaSlova
Cycloaddition reactions; Cytotoxicity; Alkynylpurines
n5:klicoveSlovo
n6:Alkynylpurines n6:Cycloaddition%20reactions n6:Cytotoxicity
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[6D5AF5D4DFAB]
n5:nazevZdroje
Collection of Czechoslovak Chemical Communications
n5:obor
n21:CC
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
5
n5:projekt
n11:LC06070 n11:GA203%2F09%2F1552
n5:rokUplatneniVysledku
n8:2011
n5:svazekPeriodika
76
n5:tvurceVysledku
Křováček, Martin Císařová, Ivana Dvořák, Dalimil Dvořáková, Hana Votruba, Ivan
n5:zamer
n7:AV0Z40550506
s:issn
0010-0765
s:numberOfPages
20
n10:doi
10.1135/cccc2011176
n14:organizacniJednotka
22810