This HTML5 document contains 48 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n9http://localhost/temp/predkladatel/
n19http://linked.opendata.cz/resource/domain/vavai/projekt/
n11http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n13http://linked.opendata.cz/ontology/domain/vavai/
n8http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F60461373%3A22340%2F14%3A43897587%21RIV15-GA0-22340___/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n12http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n10http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F14%3A43897587%21RIV15-GA0-22340___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1002/ejoc.201301517
dcterms:description
An efficient approach for the synthesis of unsymmetrically substituted Troger's base derivatives is reported. This approach is based on the N-alkylation of an arylamine by tert-butyl [2-(bromomethyl)aryl]carbamate to give the corresponding diamine, which is subsequently converted into a Troger's base derivative using paraformaldehyde in trifluoroacetic acid. The mild conditions of this approach allow the preparation of Troger's base derivatives bearing electron-withdrawing functional groups sensitive to reducing conditions, as demonstrated by the preparation of twelve Troger's base derivatives in overall yields of 62 to 76%. An efficient approach for the synthesis of unsymmetrically substituted Troger's base derivatives is reported. This approach is based on the N-alkylation of an arylamine by tert-butyl [2-(bromomethyl)aryl]carbamate to give the corresponding diamine, which is subsequently converted into a Troger's base derivative using paraformaldehyde in trifluoroacetic acid. The mild conditions of this approach allow the preparation of Troger's base derivatives bearing electron-withdrawing functional groups sensitive to reducing conditions, as demonstrated by the preparation of twelve Troger's base derivatives in overall yields of 62 to 76%.
dcterms:title
Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction
skos:prefLabel
Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction
skos:notation
RIV/60461373:22340/14:43897587!RIV15-GA0-22340___
n3:aktivita
n18:P
n3:aktivity
P(GAP303/11/1291)
n3:cisloPeriodika
13
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n11:3698106 n11:2796546 n11:2012707 n11:8695822
n3:druhVysledku
n16:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
49055
n3:idVysledku
RIV/60461373:22340/14:43897587
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Amines; Cyclization; Fused-ring systems; Nitrogen heterocycles; Synthetic methods
n3:klicoveSlovo
n7:Synthetic%20methods n7:Cyclization n7:Nitrogen%20heterocycles n7:Amines n7:Fused-ring%20systems
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[74376E2264C2]
n3:nazevZdroje
European Journal of Organic Chemistry
n3:obor
n6:CC
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n19:GAP303%2F11%2F1291
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
2014
n3:tvurceVysledku
Havlík, Martin Dolenský, Bohumil Král, Vladimír Jakubek, Milan
n3:wos
000334783300020
s:issn
1434-193X
s:numberOfPages
8
n12:doi
10.1002/ejoc.201301517
n9:organizacniJednotka
22340