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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F13%3A43895776%21RIV14-MSM-22340___
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0006349513007054
dcterms:description
We study effects of oscillatory convective flow in extracellular space on the velocity of chemical signal propagation having a form of a front wave above a cellular layer. We found that the time-averaged propagation velocity under oscillatory flow for a particular Peclet number amplitude is slower than the velocity under steady laminar flow regime for the same value of the Peclet number, but significantly faster than under no-flow conditions. We derive asymptotic values of the propagation velocity and asymptotic characteristics of the corresponding concentration fronts in high- and low-frequency regimes and show that the reason for the observed velocity increase under the oscillatory flow stems from a nonlinear dependence of the propagation velocity on the Peclet number, particularly from the convex character of the dependence. Our findings suggest that the specific responses of cellular cultures to different flow conditions in the extracellular space (for example, expression of atherosclerosis protective genes under steady laminar flow but not under oscillatory flow) is a consequence of a nonlinear coupling between the extracellular transport and complex intracellular reaction cascades forming a positive feedback loop of the autocrine signaling. This mechanism can operate independently of, or in conjunction with, a direct stress-sensing due to mechanotransduction We study effects of oscillatory convective flow in extracellular space on the velocity of chemical signal propagation having a form of a front wave above a cellular layer. We found that the time-averaged propagation velocity under oscillatory flow for a particular Peclet number amplitude is slower than the velocity under steady laminar flow regime for the same value of the Peclet number, but significantly faster than under no-flow conditions. We derive asymptotic values of the propagation velocity and asymptotic characteristics of the corresponding concentration fronts in high- and low-frequency regimes and show that the reason for the observed velocity increase under the oscillatory flow stems from a nonlinear dependence of the propagation velocity on the Peclet number, particularly from the convex character of the dependence. Our findings suggest that the specific responses of cellular cultures to different flow conditions in the extracellular space (for example, expression of atherosclerosis protective genes under steady laminar flow but not under oscillatory flow) is a consequence of a nonlinear coupling between the extracellular transport and complex intracellular reaction cascades forming a positive feedback loop of the autocrine signaling. This mechanism can operate independently of, or in conjunction with, a direct stress-sensing due to mechanotransduction
dcterms:title
Oscillatory Flow Accelerates Autocrine Signaling due to Nonlinear Effect of Convection on Receptor-Related Actions Oscillatory Flow Accelerates Autocrine Signaling due to Nonlinear Effect of Convection on Receptor-Related Actions
skos:prefLabel
Oscillatory Flow Accelerates Autocrine Signaling due to Nonlinear Effect of Convection on Receptor-Related Actions Oscillatory Flow Accelerates Autocrine Signaling due to Nonlinear Effect of Convection on Receptor-Related Actions
skos:notation
RIV/60461373:22340/13:43895776!RIV14-MSM-22340___
n7:predkladatel
n20:orjk%3A22340
n3:aktivita
n14:S n14:P
n3:aktivity
P(ME10036), S
n3:cisloPeriodika
3
n3:dodaniDat
n11:2014
n3:domaciTvurceVysledku
n17:8811199 n17:6965032 n17:2329689
n3:druhVysledku
n10:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
94689
n3:idVysledku
RIV/60461373:22340/13:43895776
n3:jazykVysledku
n18:eng
n3:klicovaSlova
GENE-EXPRESSION; FLUID-FLOW; INTERSTITIAL FLOW; LAMINAR SHEAR-STRESS; OSTEOBLAST-LIKE CELLS; MORPHOGENESIS IN-VITRO; ACTIVATED PROTEIN-KINASE; VASCULAR ENDOTHELIAL-CELLS
n3:klicoveSlovo
n8:INTERSTITIAL%20FLOW n8:GENE-EXPRESSION n8:MORPHOGENESIS%20IN-VITRO n8:ACTIVATED%20PROTEIN-KINASE n8:FLUID-FLOW n8:LAMINAR%20SHEAR-STRESS n8:VASCULAR%20ENDOTHELIAL-CELLS n8:OSTEOBLAST-LIKE%20CELLS
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C12BE83D30F2]
n3:nazevZdroje
BIOPHYSICAL JOURNAL
n3:obor
n21:CI
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n12:ME10036
n3:rokUplatneniVysledku
n11:2013
n3:svazekPeriodika
105
n3:tvurceVysledku
Schreiber, Igor Přibyl, Michal Nebyla, Marek
n3:wos
000323141100031
s:issn
0006-3495
s:numberOfPages
11
n19:doi
10.1016/j.bpj.2013.06.026
n13:organizacniJednotka
22340