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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F13%3A43895758%21RIV14-GA0-22340___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
We employ numerical techniques for solving timedependent full Poisson?Nernst?Planck (PNP) equations in 2D to analyze transient behavior of a simple ion channel subject to a sudden electric potential jump across the membrane (voltage clamp). Calculated spatiotemporal profiles of the ionic concentrations and electric potential show that two principal exponential processes can be distinguished in the electrodiffusion kinetics, in agreement with original Planck?s predictions. The initial fast process corresponds to the dielectric relaxation, while the steady state is approached in a second slower exponential process attributed to the nonlinear ionic redistribution. Effects of the model parameters such as the channel length, height of the potential step, boundary concentrations, permittivity of the channel interior, and ionic mobilities on electrodiffusion kinetics are studied. Numerical solutions are used to determine spatiotemporal profiles of the electric field, ionic fluxes, and both the conductive and displacement currents. We demonstrate that the displacement current is a significant transient component of the total electric current through the channel. The presented results provide additional information about the classical voltage-clamp problem and offer further physical insights into the mechanism of electrodiffusion. The used numerical approach can be readily extended to multi-ionic models with a more structured domain geometry in 2D or 3D, and it is directly applicable to other systems, such as synthetic nanopores, nanofluidic channels, and nanopipettes. We employ numerical techniques for solving timedependent full Poisson?Nernst?Planck (PNP) equations in 2D to analyze transient behavior of a simple ion channel subject to a sudden electric potential jump across the membrane (voltage clamp). Calculated spatiotemporal profiles of the ionic concentrations and electric potential show that two principal exponential processes can be distinguished in the electrodiffusion kinetics, in agreement with original Planck?s predictions. The initial fast process corresponds to the dielectric relaxation, while the steady state is approached in a second slower exponential process attributed to the nonlinear ionic redistribution. Effects of the model parameters such as the channel length, height of the potential step, boundary concentrations, permittivity of the channel interior, and ionic mobilities on electrodiffusion kinetics are studied. Numerical solutions are used to determine spatiotemporal profiles of the electric field, ionic fluxes, and both the conductive and displacement currents. We demonstrate that the displacement current is a significant transient component of the total electric current through the channel. The presented results provide additional information about the classical voltage-clamp problem and offer further physical insights into the mechanism of electrodiffusion. The used numerical approach can be readily extended to multi-ionic models with a more structured domain geometry in 2D or 3D, and it is directly applicable to other systems, such as synthetic nanopores, nanofluidic channels, and nanopipettes.
dcterms:title
Electrodiffusion Kinetics of Ionic Transport in a Simple Membrane Channel Electrodiffusion Kinetics of Ionic Transport in a Simple Membrane Channel
skos:prefLabel
Electrodiffusion Kinetics of Ionic Transport in a Simple Membrane Channel Electrodiffusion Kinetics of Ionic Transport in a Simple Membrane Channel
skos:notation
RIV/60461373:22340/13:43895758!RIV14-GA0-22340___
n16:predkladatel
n17:orjk%3A22340
n3:aktivita
n10:P
n3:aktivity
P(GA203/09/2091)
n3:cisloPeriodika
46
n3:dodaniDat
n5:2014
n3:domaciTvurceVysledku
n9:2329689 n9:4292367
n3:druhVysledku
n6:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
72376
n3:idVysledku
RIV/60461373:22340/13:43895758
n3:jazykVysledku
n20:eng
n3:klicovaSlova
ryanodine receptor; Poisson equation; numerical-solution; diffuse double-layer; Nernst-Planck equations; calcium-release channel
n3:klicoveSlovo
n4:ryanodine%20receptor n4:calcium-release%20channel n4:Poisson%20equation n4:numerical-solution n4:Nernst-Planck%20equations n4:diffuse%20double-layer
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[B6391D0B3515]
n3:nazevZdroje
JOURNAL OF PHYSICAL CHEMISTRY B
n3:obor
n14:CI
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:projekt
n13:GA203%2F09%2F2091
n3:rokUplatneniVysledku
n5:2013
n3:svazekPeriodika
117
n3:tvurceVysledku
Valent, Ivan Neogrády, Pavel Petrovič, Pavol Marek, Miloš Schreiber, Igor
n3:wos
000324296400022
s:issn
1520-6106
s:numberOfPages
11
n19:doi
10.1021/jp407492q
n11:organizacniJednotka
22340