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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F13%3A43895520%21RIV14-MSM-22340___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking ? namely temperature and the cholesterol:DPPC ratio ? were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes ?on-demand? by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel?liposome composites potential candidates for applications such as controlled drug delivery or study of reaction?diffusion phenomena in compartmentalised systems. Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking ? namely temperature and the cholesterol:DPPC ratio ? were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes ?on-demand? by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel?liposome composites potential candidates for applications such as controlled drug delivery or study of reaction?diffusion phenomena in compartmentalised systems.
dcterms:title
Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes
skos:prefLabel
Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes Encapsulation stability and temperature-dependent release kinetics from hydrogel-immobilised liposomes
skos:notation
RIV/60461373:22340/13:43895520!RIV14-MSM-22340___
n16:predkladatel
n17:orjk%3A22340
n3:aktivita
n4:S
n3:aktivity
S
n3:cisloPeriodika
15 March 2013
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n11:4274482 n11:2359626 n11:4022378 n11:2182270
n3:druhVysledku
n8:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
72757
n3:idVysledku
RIV/60461373:22340/13:43895520
n3:jazykVysledku
n7:eng
n3:klicovaSlova
Diffusion; Controlled release; Alginate; Hydrogel; Liposomes
n3:klicoveSlovo
n12:Liposomes n12:Diffusion n12:Hydrogel n12:Controlled%20release n12:Alginate
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[91CEEC9E8C79]
n3:nazevZdroje
Journal of Colloid and Interface Science
n3:obor
n9:CI
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n15:2013
n3:svazekPeriodika
394
n3:tvurceVysledku
Dohnal, Jiří Ullrich, Martin Štěpánek, František Hanuš, Jaroslav
n3:wos
000315325400048
s:issn
0021-9797
s:numberOfPages
6
n10:doi
10.1016/j.jcis.2012.11.016
n6:organizacniJednotka
22340