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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F13%3A43895518%21RIV14-MSM-22340___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Recent advances in the fabrication, characterization and application of micro- and nano-particles that possess a non-uniform internal structure are reviewed. The particle structures include core-shell particles, particles with multiple cores or a multi-layered structure, porous particles with both regular and random pore structure, as well as complex composite particles possessing several of the above features. Particles based on ?hard? inorganic materials such as silica, ?soft? organic materials such as polymers and their composites are considered. The fabrication approaches include bottom-up self-assembly techniques, templating methods, microfluidics, and various emulsion-based routes to structured micro- and nano-particle formation, combined with both physical (e.g. Pickering emulsions) and chemical (e.g. polymerization, precipitation) processes for the material deposition. The applications of the structured particles for the encapsulation and controlled delivery of active substances are then reviewed with emphasis on those systems where the complex particle structure can provide specific benefits such as in-situ formation of the active substance or precise control over the release profile. Likely future research directions and prospects are discussed. Recent advances in the fabrication, characterization and application of micro- and nano-particles that possess a non-uniform internal structure are reviewed. The particle structures include core-shell particles, particles with multiple cores or a multi-layered structure, porous particles with both regular and random pore structure, as well as complex composite particles possessing several of the above features. Particles based on ?hard? inorganic materials such as silica, ?soft? organic materials such as polymers and their composites are considered. The fabrication approaches include bottom-up self-assembly techniques, templating methods, microfluidics, and various emulsion-based routes to structured micro- and nano-particle formation, combined with both physical (e.g. Pickering emulsions) and chemical (e.g. polymerization, precipitation) processes for the material deposition. The applications of the structured particles for the encapsulation and controlled delivery of active substances are then reviewed with emphasis on those systems where the complex particle structure can provide specific benefits such as in-situ formation of the active substance or precise control over the release profile. Likely future research directions and prospects are discussed.
dcterms:title
Compartmentalized and Internally Structured Particles for Drug Delivery - A Review Compartmentalized and Internally Structured Particles for Drug Delivery - A Review
skos:prefLabel
Compartmentalized and Internally Structured Particles for Drug Delivery - A Review Compartmentalized and Internally Structured Particles for Drug Delivery - A Review
skos:notation
RIV/60461373:22340/13:43895518!RIV14-MSM-22340___
n8:predkladatel
n9:orjk%3A22340
n3:aktivita
n18:R
n3:aktivity
R
n3:cisloPeriodika
35
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n4:3825361 n4:4022378
n3:druhVysledku
n19:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
66386
n3:idVysledku
RIV/60461373:22340/13:43895518
n3:jazykVysledku
n12:eng
n3:klicovaSlova
microstructure.; hollow core particles; colloidosomes; controlled release; Encapsulation
n3:klicoveSlovo
n5:colloidosomes n5:microstructure. n5:hollow%20core%20particles n5:controlled%20release n5:Encapsulation
n3:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n3:kontrolniKodProRIV
[E69263DE0600]
n3:nazevZdroje
Current Pharmaceutical Design
n3:obor
n11:CI
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n15:2013
n3:svazekPeriodika
19
n3:tvurceVysledku
Štěpánek, František Čejková, Jitka
s:issn
1381-6128
s:numberOfPages
17
n16:doi
10.2174/1381612811319350007
n6:organizacniJednotka
22340