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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F12%3A43893584%21RIV13-MSM-22340___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
This study is concerned with quantifying the effect of primary particle size polydispersity on granule inhomogeneity for fluid-bed granulation. Specifically, it looks at how the variability in the PSD affects key granule properties at the granulation end-point. For the first time, the distribution of primary particles among different size fractions of the final granules was investigated computationally, together with experimental validation. Granulation was carried out from primary particles with the same mean size but different widths of the size distribution and the granules were subsequently %22disassembled%22 both physically and computationally to analyze their composition. The particle size distribution did not have any effect on the size distribution of the granules, but strongly influenced their composition and porosity. Interestingly, the incidence of coarse primary particles (}180 mu m) was highest within the smallest granule size fractions, and conversely, large granules contained predominantly fine ({125 mu m) primary particles. These findings have significant implications for the granulation of heterogeneous powder mixtures (e.g. API and excipient). This study is concerned with quantifying the effect of primary particle size polydispersity on granule inhomogeneity for fluid-bed granulation. Specifically, it looks at how the variability in the PSD affects key granule properties at the granulation end-point. For the first time, the distribution of primary particles among different size fractions of the final granules was investigated computationally, together with experimental validation. Granulation was carried out from primary particles with the same mean size but different widths of the size distribution and the granules were subsequently %22disassembled%22 both physically and computationally to analyze their composition. The particle size distribution did not have any effect on the size distribution of the granules, but strongly influenced their composition and porosity. Interestingly, the incidence of coarse primary particles (}180 mu m) was highest within the smallest granule size fractions, and conversely, large granules contained predominantly fine ({125 mu m) primary particles. These findings have significant implications for the granulation of heterogeneous powder mixtures (e.g. API and excipient).
dcterms:title
A quantitative assessment of the influence of primary particle size polydispersity on granule inhomogeneity A quantitative assessment of the influence of primary particle size polydispersity on granule inhomogeneity
skos:prefLabel
A quantitative assessment of the influence of primary particle size polydispersity on granule inhomogeneity A quantitative assessment of the influence of primary particle size polydispersity on granule inhomogeneity
skos:notation
RIV/60461373:22340/12:43893584!RIV13-MSM-22340___
n8:predkladatel
n16:orjk%3A22340
n4:aktivita
n9:R
n4:aktivity
R
n4:cisloPeriodika
neuveden
n4:dodaniDat
n18:2013
n4:domaciTvurceVysledku
n11:4022378
n4:druhVysledku
n5:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
120540
n4:idVysledku
RIV/60461373:22340/12:43893584
n4:jazykVysledku
n15:eng
n4:klicovaSlova
Fluid-bed; Granule inhomogeneity; Porosity; Particle size distribution; Multi-dimensional population balance model; Granulation
n4:klicoveSlovo
n12:Porosity n12:Fluid-bed n12:Particle%20size%20distribution n12:Granule%20inhomogeneity n12:Multi-dimensional%20population%20balance%20model n12:Granulation
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[1050B70AAF91]
n4:nazevZdroje
Chemical Engineering Science
n4:obor
n17:CI
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n18:2012
n4:svazekPeriodika
71
n4:tvurceVysledku
Štěpánek, František Ramachandran, Rohit Chaudhury, Anwesha Ansari, Mansoor A. Prakash, Anuj V. Kapadia, Avi
n4:wos
000300235600012
s:issn
0009-2509
s:numberOfPages
7
n6:doi
10.1016/j.ces.2011.11.045
n3:organizacniJednotka
22340