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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F12%3A43893581%21RIV13-MSM-22340___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
A novel method for the fabrication of cell-like microparticles consisting of a hydrogel core and a mesoporous silica shell has been developed. It consists of two steps: (i) inkjet fabrication of calcium alginate cores in the size range of 40-90 mu m that can contain immobilised nanoparticles and liposome-based internal compartments: (ii) a sol-gel process for depositing a thin mesoporous silica layer on the microparticle surface using alkoxysilane precursors. The structure of the silica coating has been investigated and its effect on the diffusion rates of proteins with increasing molecular weight (lysozyme, myoglobin, ovalbumin and BSA) has been determined. The silica shell was shown to act as an efficient semi-permeable barrier that allows the diffusion of smaller proteins but rejects larger ones. (C) 2012 Elsevier B.V. All rights reserved. A novel method for the fabrication of cell-like microparticles consisting of a hydrogel core and a mesoporous silica shell has been developed. It consists of two steps: (i) inkjet fabrication of calcium alginate cores in the size range of 40-90 mu m that can contain immobilised nanoparticles and liposome-based internal compartments: (ii) a sol-gel process for depositing a thin mesoporous silica layer on the microparticle surface using alkoxysilane precursors. The structure of the silica coating has been investigated and its effect on the diffusion rates of proteins with increasing molecular weight (lysozyme, myoglobin, ovalbumin and BSA) has been determined. The silica shell was shown to act as an efficient semi-permeable barrier that allows the diffusion of smaller proteins but rejects larger ones. (C) 2012 Elsevier B.V. All rights reserved.
dcterms:title
Towards the inkjet fabrication of artificial cells Towards the inkjet fabrication of artificial cells
skos:prefLabel
Towards the inkjet fabrication of artificial cells Towards the inkjet fabrication of artificial cells
skos:notation
RIV/60461373:22340/12:43893581!RIV13-MSM-22340___
n5:predkladatel
n18:orjk%3A22340
n3:aktivita
n17:S
n3:aktivity
S
n3:cisloPeriodika
neuveden
n3:dodaniDat
n13:2013
n3:domaciTvurceVysledku
n4:4022378 n4:4631439 n4:2359626
n3:druhVysledku
n16:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
174733
n3:idVysledku
RIV/60461373:22340/12:43893581
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Liposome; Protein diffusion; Alginate; Sol-gel method; Silica
n3:klicoveSlovo
n7:Silica n7:Liposome n7:Sol-gel%20method n7:Protein%20diffusion n7:Alginate
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[5A4723F8D4E5]
n3:nazevZdroje
Colloids and Surfaces A: Physicochemical and Engineering Aspects
n3:obor
n6:CI
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n13:2012
n3:svazekPeriodika
410
n3:tvurceVysledku
Štěpánek, František Hanuš, Jaroslav Haufová, Petra Dohnal, Jiří
n3:wos
000307797900008
s:issn
0927-7757
s:numberOfPages
7
n12:doi
10.1016/j.colsurfa.2012.06.014
n9:organizacniJednotka
22340