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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F10%3A00023202%21RIV11-GA0-22340___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
In the field of medicinal chemistry, cobalt bis(dicarbollide) derivatives are promising therapeutic agents. The potential pharmaceutical utilization of metallacarboranes is complicated due to spontaneous self-assembling in water. This problem can be solved by using suitable deaggregating agent. We present here the comprehensive screen of substituted cobalt bis(dicarbollide) derivatives with cyclodextrin derivatives, classical surfactants and amphiphilic copolymers to find general biocompatible excipients. Preliminary results are obtained by using UV/Vis spectroscopy as the technique with the best ratio of applicable information to time and source dependence. In the field of medicinal chemistry, cobalt bis(dicarbollide) derivatives are promising therapeutic agents. The potential pharmaceutical utilization of metallacarboranes is complicated due to spontaneous self-assembling in water. This problem can be solved by using suitable deaggregating agent. We present here the comprehensive screen of substituted cobalt bis(dicarbollide) derivatives with cyclodextrin derivatives, classical surfactants and amphiphilic copolymers to find general biocompatible excipients. Preliminary results are obtained by using UV/Vis spectroscopy as the technique with the best ratio of applicable information to time and source dependence.
dcterms:title
Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients
skos:prefLabel
Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients
skos:notation
RIV/60461373:22340/10:00023202!RIV11-GA0-22340___
n3:aktivita
n18:P
n3:aktivity
P(GA203/09/1311), P(KAN200100801), P(LC512)
n3:cisloPeriodika
3
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n9:9628924 n9:2796546 n9:2500698
n3:druhVysledku
n17:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
288520
n3:idVysledku
RIV/60461373:22340/10:00023202
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Cobalt bis(dicarbollide); Metallacarborane; Excipient; Solubilization; Deaggregation; Cyclodextrin; Surfactant Cobalt bis(dicarbollide); Metallacarborane; Excipient; Solubilization; Deaggregation; Cyclodextrin; Surfactant
n3:klicoveSlovo
n4:Excipient n4:Surfactant%20Cobalt%20bis%28dicarbollide%29 n4:Solubilization n4:Cobalt%20bis%28dicarbollide%29 n4:Metallacarborane n4:Cyclodextrin n4:Surfactant n4:Deaggregation
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[08D14F6551F5]
n3:nazevZdroje
Bioorganic & Medicinal Chemistry Letters
n3:obor
n5:CB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n14:LC512 n14:GA203%2F09%2F1311 n14:KAN200100801
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
20
n3:tvurceVysledku
Kaplánek, Robert Král, Vladimír Rak, Jakub
n3:wos
000273783800056
s:issn
0960-894X
s:numberOfPages
4
n16:organizacniJednotka
22340