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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F08%3A00020747%21RIV09-MSM-22340___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
The relationship between microstructure and dissolution rate of three-component granules was investigated. Granules were prepared by fluid bed granulation from sucrose spheres as model excipient, sodium chloride as model active ingredient, and polyethylene glycol (PEG) as in situ melt binder. A novel method for controlling the distribution of active ingredient within the granule was developed, based on suspending its particles in the binder prior to granulation. Granule microstructure was varied by systematically changing the NaCl particle size and the active/excipient ratio in granules. The dissolution rate of granules in water was measured by conductometry. A minimum was found in the functional dependence of dissolution time on NaCl fraction in the granule, in line with earlier computer simulations. The primary particle size was found to influence dissolution time in a nonlinear way depending on the fraction of available particle surface immersed in the binder. The intrinsic binder dissolution can t The relationship between microstructure and dissolution rate of three-component granules was investigated. Granules were prepared by fluid bed granulation from sucrose spheres as model excipient, sodium chloride as model active ingredient, and polyethylene glycol (PEG) as in situ melt binder. A novel method for controlling the distribution of active ingredient within the granule was developed, based on suspending its particles in the binder prior to granulation. Granule microstructure was varied by systematically changing the NaCl particle size and the active/excipient ratio in granules. The dissolution rate of granules in water was measured by conductometry. A minimum was found in the functional dependence of dissolution time on NaCl fraction in the granule, in line with earlier computer simulations. The primary particle size was found to influence dissolution time in a nonlinear way depending on the fraction of available particle surface immersed in the binder. The intrinsic binder dissolution can t Práce popisuje experimentální studii vlivu složení a mikrostruktury granulí obsahujících dva typy primárních částic a pojivo na rychost vylučování složek a celkovou rychlost rozpouštění. Granule byly vytvořeny ve fluidním granulátoru a rychlost rozpouštění byla studována konduktometricky. Poprvé byla experimentálně ověřena existence maxima rozpouštěcí rychlosti v závislosti na obsahu aktivní složky v granuli.
dcterms:title
Vznik mikrostruktury ve třísložkové granulaci a její vliv na rozpouštění The evolution of microstructure in three-component granulation and its effect on dissolution The evolution of microstructure in three-component granulation and its effect on dissolution
skos:prefLabel
The evolution of microstructure in three-component granulation and its effect on dissolution The evolution of microstructure in three-component granulation and its effect on dissolution Vznik mikrostruktury ve třísložkové granulaci a její vliv na rozpouštění
skos:notation
RIV/60461373:22340/08:00020747!RIV09-MSM-22340___
n4:aktivita
n10:S
n4:aktivity
S
n4:cisloPeriodika
1
n4:dodaniDat
n12:2009
n4:domaciTvurceVysledku
n13:4022378
n4:druhVysledku
n9:J
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
366934
n4:idVysledku
RIV/60461373:22340/08:00020747
n4:jazykVysledku
n14:eng
n4:klicovaSlova
dissolution; granulation; melt binder; microstructure; particle size; product design
n4:klicoveSlovo
n8:dissolution n8:particle%20size n8:melt%20binder n8:granulation n8:microstructure n8:product%20design
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[2A6B45EE55C1]
n4:nazevZdroje
Particulate Science and Technology
n4:obor
n17:CI
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
2
n4:rokUplatneniVysledku
n12:2008
n4:svazekPeriodika
26
n4:tvurceVysledku
Štěpánek, František Ansari, Mansoor
n4:wos
000252356400007
s:issn
0272-6351
s:numberOfPages
12
n16:organizacniJednotka
22340