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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F08%3A00020745%21RIV09-MSM-22340___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The relationship between the microstructure of granules and their dissolution rate has been investigated. Granules consisting of mannitol primary particles and PVP aqueous binder have been prepared by top-spray fluid-bed granulation, and granules consisting of sucrose primary particles and PEG binder by in-situ melt fluid-bed granulation. Granule microstructure has been systematically varied by manipulating the primary particle size distribution and the binder content in each case. In both cases granule porosity was found to be a decreasing function of binder content and a minimum of porosity as function of the fine/coarse primary particle mixing ratio has been observed, in line with theoretical expectations. Granule microstructures have been analysed using X-ray computed micro-tomography and compared with three-dimensional ?virtual granules? generated by a computer simulation of the agglomeration process. The dissolution rate of granules has then been measured. While porosity was found to have The relationship between the microstructure of granules and their dissolution rate has been investigated. Granules consisting of mannitol primary particles and PVP aqueous binder have been prepared by top-spray fluid-bed granulation, and granules consisting of sucrose primary particles and PEG binder by in-situ melt fluid-bed granulation. Granule microstructure has been systematically varied by manipulating the primary particle size distribution and the binder content in each case. In both cases granule porosity was found to be a decreasing function of binder content and a minimum of porosity as function of the fine/coarse primary particle mixing ratio has been observed, in line with theoretical expectations. Granule microstructures have been analysed using X-ray computed micro-tomography and compared with three-dimensional ?virtual granules? generated by a computer simulation of the agglomeration process. The dissolution rate of granules has then been measured. While porosity was found to have V této práci je popsána studie vlivu porozity granulí a obsahu a typu pojiva na rychlost jejich rozpouštění. Byly studovány granule dvojího typu ? s pojivem dodávaným jako tavenina a jako roztok. Je ukázáno, že pro danou kombinaci primárních částic a materiálu pojiva je rozhodujícím parametrem pro rozpouštění porozita granulí.
dcterms:title
Vliv mikrostruktury granulí na rychlost rozpouštění The effect of granule microstructure on dissolution rate The effect of granule microstructure on dissolution rate
skos:prefLabel
The effect of granule microstructure on dissolution rate The effect of granule microstructure on dissolution rate Vliv mikrostruktury granulí na rychlost rozpouštění
skos:notation
RIV/60461373:22340/08:00020745!RIV09-MSM-22340___
n3:aktivita
n13:S
n3:aktivity
S
n3:cisloPeriodika
2
n3:dodaniDat
n5:2009
n3:domaciTvurceVysledku
n16:4022378
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
365100
n3:idVysledku
RIV/60461373:22340/08:00020745
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Granulation; Porosity; Microstructure; Dissolution; Computer simulation; Product design
n3:klicoveSlovo
n4:Porosity n4:Dissolution n4:Computer%20simulation n4:Granulation n4:Product%20design n4:Microstructure
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[6FF30D24B6D1]
n3:nazevZdroje
Powder Technology
n3:obor
n10:CI
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n5:2008
n3:svazekPeriodika
181
n3:tvurceVysledku
Ansari, Mansoor Štěpánek, František
n3:wos
000253190200003
s:issn
0032-5910
s:numberOfPages
11
n9:organizacniJednotka
22340