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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F08%3A00020630%21RIV09-MSM-22340___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Byly syntetizovány nové konjugáty distamycinu a porfyrinu a byla studována jejich interakce s DNA z telecího brzlíku. Bylo potvrzeno, že distamycinová část konjugátu se váže do malého žlábku DNA. Porfyrinová část vykazuje interkalaci a nespecifickou elektrostatickou interakci s fosfátovými skupinami DNA. Novel distamycin-porphyrin conjugates were synthesized and their interaction with calf thymus DNA was studied. Minor groove binding of the distamycin part of the molecule was confirmed. The porphyrin part of the conjugates exhibited intercalation and the non-specific electrostatic interaction with the phosphate groups of DNA. Novel distamycin-porphyrin conjugates were synthesized and their interaction with calf thymus DNA was studied. Minor groove binding of the distamycin part of the molecule was confirmed. The porphyrin part of the conjugates exhibited intercalation and the non-specific electrostatic interaction with the phosphate groups of DNA.
dcterms:title
Spectroscopic binding studies of novel fluorescent distamycin derivatives Spektroskopická studie nových fluorescenčních derivátů distamycinu Spectroscopic binding studies of novel fluorescent distamycin derivatives
skos:prefLabel
Spektroskopická studie nových fluorescenčních derivátů distamycinu Spectroscopic binding studies of novel fluorescent distamycin derivatives Spectroscopic binding studies of novel fluorescent distamycin derivatives
skos:notation
RIV/60461373:22340/08:00020630!RIV09-MSM-22340___
n3:aktivita
n9:Z n9:P
n3:aktivity
P(GA203/06/1038), P(LC512), Z(MSM6046137307)
n3:cisloPeriodika
2
n3:dodaniDat
n8:2009
n3:domaciTvurceVysledku
n15:2696754 n15:2796546 n15:8169985
n3:druhVysledku
n19:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
396460
n3:idVysledku
RIV/60461373:22340/08:00020630
n3:jazykVysledku
n16:eng
n3:klicovaSlova
distamycin conjugates; DNA; oligonucleotidy; ECD; NMR; UV-VIS; fluorescent
n3:klicoveSlovo
n7:ECD n7:UV-VIS n7:distamycin%20conjugates n7:NMR n7:fluorescent n7:DNA n7:oligonucleotidy
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[BAAEB88D0DE4]
n3:nazevZdroje
Tetrahedron Letters
n3:obor
n12:CB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n14:LC512 n14:GA203%2F06%2F1038
n3:rokUplatneniVysledku
n8:2008
n3:svazekPeriodika
49
n3:tvurceVysledku
Foltýnová, J. Tkadlecová, Marcela Valík, Martin Král, Vladimír
n3:wos
000253006400028
n3:zamer
n13:MSM6046137307
s:issn
0040-4039
s:numberOfPages
4
n18:organizacniJednotka
22340