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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F06%3A00020163%21RIV09-MZ0-22340___
rdf:type
n17:Vysledek skos:Concept
dcterms:description
%22Head-to -head%22 oligo-N-methylpyrrole peptide dimers linked by a methano[1,5]diazocin scaffold are presented in racemic as well as chiral fashion. Their DNA binding activities were assayed on calf thymus DNA, poly(dA-dT)2 and poly(dC-dG)2 by NMR and ECD spectroscopies. and fluorescence probe displacement assay. The presented dimers prefer AT sequences, but show higher affinity to poly(dC-dG)2 than distamycin A. The (4R,9R) configuration of methanodiazocin bridge was found to be better suited for interaction with ct-DNA and poly(dA-dT)2 than (4S,9S) configuration. Byly studovány dimery tvořené dvěma oligo-N-methylpyrrolovými peptidy spojenými methano[1,5]diazocinovým strukturním motivem, a to v rcemické i chirální formě. Jejich interakce s DNA byla zkoumána pro DNA z telecího brzlíku, poly(dA-dT)2 a poly(dC-dG)2, a sice pomocí spektroskopie NMR a ECD a pomocí fluorescenčního značení. Zkoumané dimery preferují interakci se sekvencemi AT, ale vykazují vyšší afinitu k poly(dC-dG)2 než distamycin A. Konfigurace (4R,9R) na methanodiazocinovém můstku je vhodnější pro interakci s DNA z telecího brzlíku a poly(dA-dT)2 než konfigurace (4S,9S). %22Head-to -head%22 oligo-N-methylpyrrole peptide dimers linked by a methano[1,5]diazocin scaffold are presented in racemic as well as chiral fashion. Their DNA binding activities were assayed on calf thymus DNA, poly(dA-dT)2 and poly(dC-dG)2 by NMR and ECD spectroscopies. and fluorescence probe displacement assay. The presented dimers prefer AT sequences, but show higher affinity to poly(dC-dG)2 than distamycin A. The (4R,9R) configuration of methanodiazocin bridge was found to be better suited for interaction with ct-DNA and poly(dA-dT)2 than (4S,9S) configuration.
dcterms:title
Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study Použití racemických a chirálních Trögerových bazí pro syntézu distamycinu. Syntéza a studie interakce s DNA Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study
skos:prefLabel
Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study Tröger's base scaffold in racemic and chiral fashion as a spacer for bisdistamycin formation. Synthesis and DNA binding study Použití racemických a chirálních Trögerových bazí pro syntézu distamycinu. Syntéza a studie interakce s DNA
skos:notation
RIV/60461373:22340/06:00020163!RIV09-MZ0-22340___
n4:aktivita
n16:R n16:P n16:Z
n4:aktivity
P(GA203/06/1038), P(GA305/05/2030), P(LC512), P(NR8355), R, Z(AV0Z50040507)
n4:cisloPeriodika
36
n4:dodaniDat
n5:2009
n4:domaciTvurceVysledku
n8:2696754 n8:8169985 n8:2796546 n8:6334997 n8:6564844
n4:druhVysledku
n14:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
504467
n4:idVysledku
RIV/60461373:22340/06:00020163
n4:jazykVysledku
n15:eng
n4:klicovaSlova
Tröger's base; distamycin dimer; enantioselective binding; dissymmetry factor; VCD
n4:klicoveSlovo
n9:Tr%C3%B6ger%27s%20base n9:VCD n9:dissymmetry%20factor n9:distamycin%20dimer n9:enantioselective%20binding
n4:kodStatuVydavatele
BE - Belgické království
n4:kontrolniKodProRIV
[906BECCD20B4]
n4:nazevZdroje
Tetrahedron
n4:obor
n7:CB
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
8
n4:projekt
n12:GA305%2F05%2F2030 n12:NR8355 n12:LC512 n12:GA203%2F06%2F1038
n4:rokUplatneniVysledku
n5:2006
n4:svazekPeriodika
62
n4:tvurceVysledku
Foltýnová, Jarmila Urbanová, Marie Král, Vladimír Palivec, Lukáš Malina, Jaroslav Tkadlecová, Marcela Vrabec, Viktor Valík, Martin
n4:wos
000240125700021
n4:zamer
n11:AV0Z50040507
s:issn
0040-4020
s:numberOfPages
10
n19:organizacniJednotka
22340