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Statements

Subject Item
n2:RIV%2F60461373%3A22340%2F06%3A00016747%21RIV07-MSM-22340___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Simple water-soluble lanthanum and europium complexes are effective at detecting neutral sugars as well as glycolipids and phospholipids. In solutions at physiologically relevant pH the fluorescent lanthanum complex binds neutral sugars with apparent binding constants comparable to those of arylboronic acids. interference from commonly occurring anions is minimal. The europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharicle and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, lysophosphatidic acid (LPA), a biomarker for several pathological conditions including ovarian cancer, is selectively detected by the europium complex. LPA is also detected via a fluorescence increase in human plasma samples. The 2-sn-OH moiety of LPA plays a key role in promoting binding to the metal center. Other molecules found in common brain gangli Simple water-soluble lanthanum and europium complexes are effective at detecting neutral sugars as well as glycolipids and phospholipids. In solutions at physiologically relevant pH the fluorescent lanthanum complex binds neutral sugars with apparent binding constants comparable to those of arylboronic acids. interference from commonly occurring anions is minimal. The europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharicle and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, lysophosphatidic acid (LPA), a biomarker for several pathological conditions including ovarian cancer, is selectively detected by the europium complex. LPA is also detected via a fluorescence increase in human plasma samples. The 2-sn-OH moiety of LPA plays a key role in promoting binding to the metal center. Other molecules found in common brain gangli Jednoduché ve vodě rozpustné komplexy lanthanu a europia jsou účinné při detekci neutrálních cukrů stejně jako glykolipidů a fosfolipidů V roztocích s pH blízkým fyziologickému se fluorescenční komplexy lanthanu vážou na neutrální cukry s vazebnou konstantou srovnatelnou s arylboronovými kyselinami.
dcterms:title
Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers Lanthanidové komplexy jako fluorescenční indikátory pro neutrální cukry a rakovinné biomarkery
skos:prefLabel
Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers Lanthanidové komplexy jako fluorescenční indikátory pro neutrální cukry a rakovinné biomarkery Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers
skos:notation
RIV/60461373:22340/06:00016747!RIV07-MSM-22340___
n3:strany
9756-9760
n3:aktivita
n16:Z n16:P
n3:aktivity
P(GA203/06/1038), P(LC512), Z(MSM6046137307)
n3:cisloPeriodika
2
n3:dodaniDat
n13:2007
n3:domaciTvurceVysledku
n7:6314996 n7:2796546
n3:druhVysledku
n19:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
482895
n3:idVysledku
RIV/60461373:22340/06:00016747
n3:jazykVysledku
n4:eng
n3:klicovaSlova
gangliosides; lysophosphaticlic acid; salophenes; saccharides
n3:klicoveSlovo
n6:salophenes n6:lysophosphaticlic%20acid n6:saccharides n6:gangliosides
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E233513C595F]
n3:nazevZdroje
Proceedings of the National Academy of Sciences of U.S.A
n3:obor
n10:CB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
10
n3:projekt
n5:LC512 n5:GA203%2F06%2F1038
n3:rokUplatneniVysledku
n13:2006
n3:svazekPeriodika
103
n3:tvurceVysledku
Pruet, J. Escobedo, J. Crowe, W. Wang, W. Fakayode, S. Warner, I. Rusín, Oleksandr Alptürk, O. Strongin, R. Král, Vladimír
n3:zamer
n9:MSM6046137307
s:issn
1091-6490
s:numberOfPages
5
n14:organizacniJednotka
22340