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Statements

Subject Item
n2:RIV%2F60461373%3A22330%2F14%3A43898386%21RIV15-MZE-22330___
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://www.academicjournals.org/article/article1410257161_Lisov%C3%A1%20et%20al.pdf
dcterms:description
The immunomodulatory effect of nine strains of Lactobacillus plantarum by stimulation of human peripheral blood mononuclear cells (hPBMCs) from healthy donors was investigated. The production of pro-inflammatory, anti-inflammatory and regulatory cytokines by mononuclear cells following exposure of live bacterial cells was measured using multiplex analysis Luminex. The stimulation and production of cytokine by hPBMCs was evaluated to be strain specific and dependent on the density of cells used for stimulation. A significant increase of IL-6 and IL-1beta secretion was demonstrated following stimulation of hPMBCs by high densities of lactobacilli (P { 0.05). By contrast, low density of lactobacilli strains increased the production of TNF-alfa (P { 0.05) in seven out of nine strains tested. The results have also shown the importance of testing probiotics with using multiplex methods that can help to explanation of the effectiveness/ineffectiveness of probiotics in the treatment and prevention of gastrointestinal diseases and allergies. The immunomodulatory effect of nine strains of Lactobacillus plantarum by stimulation of human peripheral blood mononuclear cells (hPBMCs) from healthy donors was investigated. The production of pro-inflammatory, anti-inflammatory and regulatory cytokines by mononuclear cells following exposure of live bacterial cells was measured using multiplex analysis Luminex. The stimulation and production of cytokine by hPBMCs was evaluated to be strain specific and dependent on the density of cells used for stimulation. A significant increase of IL-6 and IL-1beta secretion was demonstrated following stimulation of hPMBCs by high densities of lactobacilli (P { 0.05). By contrast, low density of lactobacilli strains increased the production of TNF-alfa (P { 0.05) in seven out of nine strains tested. The results have also shown the importance of testing probiotics with using multiplex methods that can help to explanation of the effectiveness/ineffectiveness of probiotics in the treatment and prevention of gastrointestinal diseases and allergies.
dcterms:title
The immunomodulatory effect of Lactobacillus plantarum strains on mononuclear cells isolated from human peripheral blood. The immunomodulatory effect of Lactobacillus plantarum strains on mononuclear cells isolated from human peripheral blood.
skos:prefLabel
The immunomodulatory effect of Lactobacillus plantarum strains on mononuclear cells isolated from human peripheral blood. The immunomodulatory effect of Lactobacillus plantarum strains on mononuclear cells isolated from human peripheral blood.
skos:notation
RIV/60461373:22330/14:43898386!RIV15-MZE-22330___
n4:aktivita
n9:P
n4:aktivity
P(QJ1210376)
n4:cisloPeriodika
19
n4:dodaniDat
n14:2015
n4:domaciTvurceVysledku
n5:7210515
n4:druhVysledku
n10:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
20546
n4:idVysledku
RIV/60461373:22330/14:43898386
n4:jazykVysledku
n13:eng
n4:klicovaSlova
cytokine; immunomodulation; Lactobacillus plantarum
n4:klicoveSlovo
n7:immunomodulation n7:cytokine n7:Lactobacillus%20plantarum
n4:kodStatuVydavatele
NG - Nigerijská federativní republika
n4:kontrolniKodProRIV
[F736F60EEAF3]
n4:nazevZdroje
African Journal of Microbiology Research
n4:obor
n11:GM
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
6
n4:projekt
n15:QJ1210376
n4:rokUplatneniVysledku
n14:2014
n4:svazekPeriodika
8
n4:tvurceVysledku
Kolesár, Libor Kunová, Gabriela Lisová, Ivana Bártová, Jiřina Šalaková, Alexandra Čurda, Ladislav
s:issn
1996-0808
s:numberOfPages
4
n8:doi
10.5897/AJMR2014.6744
n17:organizacniJednotka
22330