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Statements

Subject Item
n2:RIV%2F60461373%3A22330%2F14%3A43897364%21RIV15-MSM-22330___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Formation of a mature core is a crucial event for infectivity of retroviruses such as Mason-Pfizer monkey virus (M-PMV). The process is triggered by proteolytic cleavage of the polyprotein precursor Gag, which releases matrix, capsid (CA), and nucleocapsid proteins. Once released, CA assembles to form a mature core - a hexameric lattice protein shell that protects retroviral genomic RNA. Subtle conformational changes within CA induce the transition from the immature lattice to the mature lattice. Upon release from the precursor, the initially unstructured N-terminus of CA is refolded to form a beta-hairpin stabilized by a salt bridge between the N-terminal proline and conserved aspartate. Although the crucial role of the beta-hairpin in the mature core assembly has been confirmed, its precise structural function remains poorly understood. Formation of a mature core is a crucial event for infectivity of retroviruses such as Mason-Pfizer monkey virus (M-PMV). The process is triggered by proteolytic cleavage of the polyprotein precursor Gag, which releases matrix, capsid (CA), and nucleocapsid proteins. Once released, CA assembles to form a mature core - a hexameric lattice protein shell that protects retroviral genomic RNA. Subtle conformational changes within CA induce the transition from the immature lattice to the mature lattice. Upon release from the precursor, the initially unstructured N-terminus of CA is refolded to form a beta-hairpin stabilized by a salt bridge between the N-terminal proline and conserved aspartate. Although the crucial role of the beta-hairpin in the mature core assembly has been confirmed, its precise structural function remains poorly understood.
dcterms:title
Stabilization of the beta-hairpin in Mason-Pfizer Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity Stabilization of the beta-hairpin in Mason-Pfizer Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity
skos:prefLabel
Stabilization of the beta-hairpin in Mason-Pfizer Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity Stabilization of the beta-hairpin in Mason-Pfizer Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity
skos:notation
RIV/60461373:22330/14:43897364!RIV15-MSM-22330___
n3:aktivita
n13:I
n3:aktivity
I
n3:cisloPeriodika
94
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n5:9372040 n5:9597778 n5:8571635
n3:druhVysledku
n15:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
46992
n3:idVysledku
RIV/60461373:22330/14:43897364
n3:jazykVysledku
n17:eng
n3:klicovaSlova
infectivity; for; step; critical; protein-; capsid; virus; monkey; Mason-Pfizer; beta-hairpin; the; Stabilization
n3:klicoveSlovo
n8:protein- n8:Stabilization n8:for n8:infectivity n8:the n8:critical n8:Mason-Pfizer n8:step n8:monkey n8:beta-hairpin n8:capsid n8:virus
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[65D716E818BC]
n3:nazevZdroje
Retrovirology
n3:obor
n14:EI
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n6:2014
n3:svazekPeriodika
11
n3:tvurceVysledku
Papoušková, Veronika Rumlová, Michaela Hadravová, Romana Doležal, Michal Křížová, Ivana Obr, Martin Žídek, Lukáš Ruml, Tomáš Hrabal, Richard
n3:wos
000344571100001
s:issn
1742-4690
s:numberOfPages
14
n4:doi
10.1186/s12977-014-0094-8
n18:organizacniJednotka
22330