This HTML5 document contains 53 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n9http://localhost/temp/predkladatel/
n10http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n8http://linked.opendata.cz/resource/domain/vavai/projekt/
n21http://linked.opendata.cz/resource/domain/vavai/subjekt/
n7http://linked.opendata.cz/ontology/domain/vavai/
n13http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n17http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F60461373%3A22330%2F13%3A43895382%21RIV14-GA0-22330___/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n20http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F60461373%3A22330%2F13%3A43895382%21RIV14-GA0-22330___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 mu M (8) and 23.1 +/- 4.0 mu M (9)] and cervical cancer [24.8 +/- 5.3 mu M (8) and 29.1 +/- 4.7 mu M (9)]. Only the compound 8 was adequately less active on normal human fibroblasts (40.4 +/- 11.1 mu M). The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 mu M (8) and 23.1 +/- 4.0 mu M (9)] and cervical cancer [24.8 +/- 5.3 mu M (8) and 29.1 +/- 4.7 mu M (9)]. Only the compound 8 was adequately less active on normal human fibroblasts (40.4 +/- 11.1 mu M).
dcterms:title
Amides derived from heteroaromatic amines and selected steryl hemiesters Amides derived from heteroaromatic amines and selected steryl hemiesters
skos:prefLabel
Amides derived from heteroaromatic amines and selected steryl hemiesters Amides derived from heteroaromatic amines and selected steryl hemiesters
skos:notation
RIV/60461373:22330/13:43895382!RIV14-GA0-22330___
n7:predkladatel
n21:orjk%3A22330
n3:aktivita
n16:I n16:P n16:Z
n3:aktivity
I, P(ED0007/01/01), P(GAP503/11/0616), Z(MSM6046137305)
n3:cisloPeriodika
14
n3:dodaniDat
n20:2014
n3:domaciTvurceVysledku
n10:3427668 n10:5157056 n10:8489173
n3:druhVysledku
n15:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
60231
n3:idVysledku
RIV/60461373:22330/13:43895382
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Cytotoxic activity; Amide; Lanosterol; Cholesterol; Heteroaromatic amine
n3:klicoveSlovo
n6:Heteroaromatic%20amine n6:Cytotoxic%20activity n6:Lanosterol n6:Cholesterol n6:Amide
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CC3D39E7B4D7]
n3:nazevZdroje
Steroids
n3:obor
n14:CC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n8:ED0007%2F01%2F01 n8:GAP503%2F11%2F0616
n3:rokUplatneniVysledku
n20:2013
n3:svazekPeriodika
78
n3:tvurceVysledku
Bildziukevich, Uladzimir Šaman, David Drašar, Pavel Havlíček, Libor Rárová, Lucie Wimmer, Zdenek
n3:wos
000328303300006
n3:zamer
n13:MSM6046137305
s:issn
0039-128X
s:numberOfPages
6
n17:doi
10.1016/j.steroids.2013.10.003
n9:organizacniJednotka
22330