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Statements

Subject Item
n2:RIV%2F60461373%3A22330%2F11%3A43893068%21RIV12-MSM-22330___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
This work is devoted to preparation of hydrophobically modified chitosans and evaluation of their sorption properties. N,N,(N)-Di(tri)methylchitosan (MC1) was prepared by the reaction of chitosan with methyl iodide; N,O-palmitoyl-chitosan (MC2) and N,N,(N)-di(tri)methyl-N,O-palmitoyl-chitosan (MC3) were prepared by the reaction of chitosan and MC1 with palmitoyl chloride, respectively. These modified chitosans were characterized by organic elemental analysis, FTIR, NMR, and DSC. The degrees of substitution were calculated from the N/C ratio and from the areas of NMR signals. The in vitro sorption of cholate and cholesterol by chitosan derivatives was studied in comparison with the original chitosan and cholestyramine, an effective synthetic sorbent of bile acids. It was found that MC2 and MC3 are able to bind cholesterol and bile acids, respectively, and thus can be used as cholestyramine supplements to improve cholesterol metabolism. This work is devoted to preparation of hydrophobically modified chitosans and evaluation of their sorption properties. N,N,(N)-Di(tri)methylchitosan (MC1) was prepared by the reaction of chitosan with methyl iodide; N,O-palmitoyl-chitosan (MC2) and N,N,(N)-di(tri)methyl-N,O-palmitoyl-chitosan (MC3) were prepared by the reaction of chitosan and MC1 with palmitoyl chloride, respectively. These modified chitosans were characterized by organic elemental analysis, FTIR, NMR, and DSC. The degrees of substitution were calculated from the N/C ratio and from the areas of NMR signals. The in vitro sorption of cholate and cholesterol by chitosan derivatives was studied in comparison with the original chitosan and cholestyramine, an effective synthetic sorbent of bile acids. It was found that MC2 and MC3 are able to bind cholesterol and bile acids, respectively, and thus can be used as cholestyramine supplements to improve cholesterol metabolism.
dcterms:title
Chitosan derivatives as bile acid and cholesterol sorbents Chitosan derivatives as bile acid and cholesterol sorbents
skos:prefLabel
Chitosan derivatives as bile acid and cholesterol sorbents Chitosan derivatives as bile acid and cholesterol sorbents
skos:notation
RIV/60461373:22330/11:43893068!RIV12-MSM-22330___
n15:predkladatel
n16:orjk%3A22330
n5:aktivita
n6:P n6:Z
n5:aktivity
P(GAP503/11/2479), Z(MSM6046137305)
n5:cisloPeriodika
4
n5:dodaniDat
n18:2012
n5:domaciTvurceVysledku
n8:7618727 n8:8009988 n8:9893628
n5:druhVysledku
n20:J
n5:duvernostUdaju
n17:S
n5:entitaPredkladatele
n13:predkladatel
n5:idSjednocenehoVysledku
190232
n5:idVysledku
RIV/60461373:22330/11:43893068
n5:jazykVysledku
n11:eng
n5:klicovaSlova
chitosan, hydrophobic modification, cholestyramine, in vitro sorption, cholesterol, bile acids
n5:klicoveSlovo
n10:chitosan n10:bile%20acids n10:in%20vitro%20sorption n10:hydrophobic%20modification n10:cholestyramine n10:cholesterol
n5:kodStatuVydavatele
KR - Korejská republika
n5:kontrolniKodProRIV
[52410BD6B60C]
n5:nazevZdroje
Journal of Chitin and Chitosan
n5:obor
n19:CD
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
5
n5:projekt
n7:GAP503%2F11%2F2479
n5:rokUplatneniVysledku
n18:2011
n5:svazekPeriodika
16
n5:tvurceVysledku
Dušková, Dagmar Marounek, Milan Synytsya, Andriy Tůma, Jan Čopíková, Jana
n5:zamer
n12:MSM6046137305
s:issn
1229-4160
s:numberOfPages
9
n14:organizacniJednotka
22330