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Statements

Subject Item
n2:RIV%2F60461373%3A22330%2F11%3A43892843%21RIV12-MSM-22330___
rdf:type
skos:Concept n9:Vysledek
dcterms:description
This work describes the development and validation of an offline solid-phase extraction with simultaneous cleanup capability, followed by liquid chromatography-(electrospray ionisation)-ion trap mass spectrometry, enabling the concurrent determination of 23 pharmaceuticals of diverse chemical nature, among the most consumed in Portugal, in wastewater samples. Several cleanup strategies, exploiting the physical and chemical properties of the analytes vs. interferences, alongside with the use of internal standards, were assayed in order to minimise the influence of matrix components in the ionisation efficiency of target analytes. After testing all combinations of adsorbents (normal-phase, ion exchange and mixed composition) and elution solvents, the best results were achieved with the mixed-anion exchange Oasis MAX cartridges. They provided recovery rates generally higher than 60%. The precision of the method ranged from 2% to 18% and 4% to 19% (except for diclofenac (22%) and simvastatin (26%)) for intra- and inter-day analysis, respectively. Method detection limits varied between 1 and 20 ng L(-1), while method quantification limits were { 85 ng L(-1) (both excluding ibuprofen). This analytical method was applied to gather preliminary results on influents and effluents of two wastewater treatment plants (WWTPs) located in the urban region of Porto (Portugal). Typically, paracetamol, hydrochlorothiazide, furosemide, naproxen, ibuprofen, diclofenac and bezafibrate were detected in concentrations ranging from 1 to 20 mu g L(-1), while gemfibrozil, simvastatin, ketoprofen, azithromycin, bisoprolol, lorazepam and paroxetine were quantified in levels below 1 mu g L(-1). These WWTPs were given particular attention since they discharge their effluents into the Douro river, where water is extracted for the production of drinking water. Some sampling spots in this river were also analysed. This work describes the development and validation of an offline solid-phase extraction with simultaneous cleanup capability, followed by liquid chromatography-(electrospray ionisation)-ion trap mass spectrometry, enabling the concurrent determination of 23 pharmaceuticals of diverse chemical nature, among the most consumed in Portugal, in wastewater samples. Several cleanup strategies, exploiting the physical and chemical properties of the analytes vs. interferences, alongside with the use of internal standards, were assayed in order to minimise the influence of matrix components in the ionisation efficiency of target analytes. After testing all combinations of adsorbents (normal-phase, ion exchange and mixed composition) and elution solvents, the best results were achieved with the mixed-anion exchange Oasis MAX cartridges. They provided recovery rates generally higher than 60%. The precision of the method ranged from 2% to 18% and 4% to 19% (except for diclofenac (22%) and simvastatin (26%)) for intra- and inter-day analysis, respectively. Method detection limits varied between 1 and 20 ng L(-1), while method quantification limits were { 85 ng L(-1) (both excluding ibuprofen). This analytical method was applied to gather preliminary results on influents and effluents of two wastewater treatment plants (WWTPs) located in the urban region of Porto (Portugal). Typically, paracetamol, hydrochlorothiazide, furosemide, naproxen, ibuprofen, diclofenac and bezafibrate were detected in concentrations ranging from 1 to 20 mu g L(-1), while gemfibrozil, simvastatin, ketoprofen, azithromycin, bisoprolol, lorazepam and paroxetine were quantified in levels below 1 mu g L(-1). These WWTPs were given particular attention since they discharge their effluents into the Douro river, where water is extracted for the production of drinking water. Some sampling spots in this river were also analysed.
dcterms:title
Cleanup strategies and advantages in the determination of several therapeutic classes of pharmaceuticals in wastewater samples by SPE-LC-MS/MS Cleanup strategies and advantages in the determination of several therapeutic classes of pharmaceuticals in wastewater samples by SPE-LC-MS/MS
skos:prefLabel
Cleanup strategies and advantages in the determination of several therapeutic classes of pharmaceuticals in wastewater samples by SPE-LC-MS/MS Cleanup strategies and advantages in the determination of several therapeutic classes of pharmaceuticals in wastewater samples by SPE-LC-MS/MS
skos:notation
RIV/60461373:22330/11:43892843!RIV12-MSM-22330___
n9:predkladatel
n10:orjk%3A22330
n4:aktivita
n8:Z
n4:aktivity
Z(MSM6046137305)
n4:cisloPeriodika
2
n4:dodaniDat
n11:2012
n4:domaciTvurceVysledku
n16:8580588
n4:druhVysledku
n18:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
190548
n4:idVysledku
RIV/60461373:22330/11:43892843
n4:jazykVysledku
n14:eng
n4:klicovaSlova
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) Surface water; MAX cartridges; Cleanup; Wastewater; Pharmaceuticals
n4:klicoveSlovo
n12:Cleanup n12:Liquid%20chromatography-tandem%20mass%20spectrometry%20%28LC-MS%2FMS%29%20Surface%20water n12:Wastewater n12:MAX%20cartridges n12:Pharmaceuticals
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[B7B8E8363E0E]
n4:nazevZdroje
Analytical and Bioanalytical Chemistry
n4:obor
n5:DJ
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n11:2011
n4:svazekPeriodika
399
n4:tvurceVysledku
Alpendurada, M. F. Sousa, M. A. Cunha, E. Goncalves, C. Hajšlová, Jana
n4:wos
000285781900028
n4:zamer
n17:MSM6046137305
s:issn
1618-2642
s:numberOfPages
16
n15:doi
10.1007/s00216-010-4297-0
n19:organizacniJednotka
22330