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Statements

Subject Item
n2:RIV%2F60461373%3A22330%2F11%3A43891709%21RIV12-MSM-22330___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Derivatives of 1,4-dihydro-4-oxoquinoline substituted at 4-pyridone or/and benzene moieties were synthesized (Q1-Q17), and characterized by UV/vis and FT-IR spectroscopy. In dimethylsulfoxide and acetonitrile solvents a significant influence of the substituent's character and position on the quinolone skeleton was observed on the absorption bands in the UVA region (315-400 nm). Electron-withdrawing substituents (nitro, cyano, acetyl or trifluoroacetyl) caused a red shift, resulting in the effective absorption of UVA light. Photoinduced generation of superoxide radical anion and singlet oxygen upon UVA irradiation was followed by EPR spectroscopy using in situ spin trapping technique; 4-hydroxy-2,2,6,6-piperidine (TMP) served for singlet oxygen ((1)O(2)) detection. An efficient generation of superoxide radical anions and singlet oxygen was observed predominantly for nitro-substituted quinolones. The effect of quinolones on proliferation of HL-60 cells was monitored. Derivatives of 1,4-dihydro-4-oxoquinoline substituted at 4-pyridone or/and benzene moieties were synthesized (Q1-Q17), and characterized by UV/vis and FT-IR spectroscopy. In dimethylsulfoxide and acetonitrile solvents a significant influence of the substituent's character and position on the quinolone skeleton was observed on the absorption bands in the UVA region (315-400 nm). Electron-withdrawing substituents (nitro, cyano, acetyl or trifluoroacetyl) caused a red shift, resulting in the effective absorption of UVA light. Photoinduced generation of superoxide radical anion and singlet oxygen upon UVA irradiation was followed by EPR spectroscopy using in situ spin trapping technique; 4-hydroxy-2,2,6,6-piperidine (TMP) served for singlet oxygen ((1)O(2)) detection. An efficient generation of superoxide radical anions and singlet oxygen was observed predominantly for nitro-substituted quinolones. The effect of quinolones on proliferation of HL-60 cells was monitored.
dcterms:title
Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives
skos:prefLabel
Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives Spectroscopic characterization and photoinduced processes of 4-oxoquinoline derivatives
skos:notation
RIV/60461373:22330/11:43891709!RIV12-MSM-22330___
n8:predkladatel
n9:orjk%3A22330
n3:aktivita
n13:S
n3:aktivity
S
n3:cisloPeriodika
1
n3:dodaniDat
n14:2012
n3:domaciTvurceVysledku
n6:7075219
n3:druhVysledku
n11:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
231384
n3:idVysledku
RIV/60461373:22330/11:43891709
n3:jazykVysledku
n5:eng
n3:klicovaSlova
HL-60 cells; Cytotoxic activity; Reactive oxygen species; Spin trapping technique; EPR spectroscopy; Cathodic reduction; FT-IR; UV/vis spectroscopy; 4-Oxoquinolines (quinolones)
n3:klicoveSlovo
n4:FT-IR n4:4-Oxoquinolines%20%28quinolones%29 n4:Spin%20trapping%20technique n4:UV%2Fvis%20spectroscopy n4:HL-60%20cells n4:Cytotoxic%20activity n4:EPR%20spectroscopy n4:Reactive%20oxygen%20species n4:Cathodic%20reduction
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[7726CB1619B8]
n3:nazevZdroje
Journal of Photochemistry and Photobiology A: Chemistry
n3:obor
n17:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n14:2011
n3:svazekPeriodika
224
n3:tvurceVysledku
Jantova, Sona Bella, Maros Füzik, Tibor Barbierikova, Zuzana Brezova, Vlasta Stasko, Andrej Milata, Viktor Lietava, Jozef Dvoranova, Dana
n3:wos
000297189600017
s:issn
1010-6030
s:numberOfPages
12
n7:organizacniJednotka
22330