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Statements

Subject Item
n2:RIV%2F60461373%3A22330%2F03%3A00008965%21RIV%2F2004%2FGA0%2F223304%2FN
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance. To further investigate the effects of resistin on glucose metabolism, we derived a novel transgenic strain of spontaneously hypertensive rats expressing the mouse resistin gene under the control of the fat-specific aP2 promoter and also performed in vitro studies of the effects of recombinant resistin on glucose metabolism in isolated skeletal muscle. Expression of the resistin transgene was detected by Northern blot analysis in adipose tissue and by real-time PCR in skeletal muscle and was associated with increased serum fatty acids and muscle triglycerides, impaired skeletal muscle glucose metabolism, and glucose intolerance in the absence of any changes in serum resistin concentrations. In skeletal muscle isolated from non-transgenic spontaneously hypertensive rats, in vitro incubation with recombinant resistin significantly inhibited insuli Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance. To further investigate the effects of resistin on glucose metabolism, we derived a novel transgenic strain of spontaneously hypertensive rats expressing the mouse resistin gene under the control of the fat-specific aP2 promoter and also performed in vitro studies of the effects of recombinant resistin on glucose metabolism in isolated skeletal muscle. Expression of the resistin transgene was detected by Northern blot analysis in adipose tissue and by real-time PCR in skeletal muscle and was associated with increased serum fatty acids and muscle triglycerides, impaired skeletal muscle glucose metabolism, and glucose intolerance in the absence of any changes in serum resistin concentrations. In skeletal muscle isolated from non-transgenic spontaneously hypertensive rats, in vitro incubation with recombinant resistin significantly inhibited insuli
dcterms:title
Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat
skos:prefLabel
Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat
skos:notation
RIV/60461373:22330/03:00008965!RIV/2004/GA0/223304/N
n3:strany
45209-15
n3:aktivita
n11:P
n3:aktivity
P(GA301/03/0751)
n3:cisloPeriodika
46
n3:dodaniDat
n16:2004
n3:domaciTvurceVysledku
n13:2655586
n3:druhVysledku
n14:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
631338
n3:idVysledku
RIV/60461373:22330/03:00008965
n3:jazykVysledku
n7:eng
n3:klicovaSlova
Proteins; Muscle; Genetic engineering; Living systems studies; Cells; Oils and fats; Insulin; Metabolism; Glucose; Genes; Fatty acids;
n3:klicoveSlovo
n4:Living%20systems%20studies n4:Proteins n4:Metabolism n4:Genetic%20engineering n4:Insulin n4:Muscle n4:Glucose n4:Cells n4:Genes n4:Fatty%20acids n4:Oils%20and%20fats
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[607FF59A434B]
n3:nazevZdroje
The Journal of biological chemistry
n3:obor
n6:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n5:GA301%2F03%2F0751
n3:rokUplatneniVysledku
n16:2003
n3:svazekPeriodika
278
n3:tvurceVysledku
Wang, Jiaming Jansa, Petr Pravenec, Michal Mlejnek, Petr Landa, Vladimir Kurtz, Theodore Zídek, Václav Kazdová, Ludmila
s:issn
0021-9258
s:numberOfPages
7
n9:organizacniJednotka
22330