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Statements

Subject Item
n2:RIV%2F60461373%3A22310%2F14%3A43898271%21RIV15-MSM-22310___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://www.dissolutiontech.com/DTresour/201411Articles/DT201411_A04.pdf
dcterms:description
The release rate of an active ingredient from a dosage form may be affected by the agglomeration of an active ingredient before tablet compression. This study is aimed at establishing the effects of the agglomerates on active ingredient release profiles. A model substance, caffeine, was tested in the powdered form and in the two agglomerated forms prepared by wet granulation and compaction. The profiles of caffeine release from these forms were measured using a flow-through cell dissolution apparatus (USP 4) in an open-loop arrangement. To identify the particular processes responsible for the differences in the dissolution profiles of the model forms, we developed a mathematical description of the dissolution profiles. Using this mathematical approach, we proposed that caffeine was adsorbed to the microcrystalline cellulose present in the granulated and compacted form and that diffusion of the active ingredient was inhibited in the presence of a binder in the granulate. Both of these effects resulted in imperfections in the shape of dissolution profiles and in a decrease in the dissolution rate of caffeine. The mathematical model is based on generic parameters, thus it is transferable to other pharmaceutical substances in powdered and agglomerated forms. The release rate of an active ingredient from a dosage form may be affected by the agglomeration of an active ingredient before tablet compression. This study is aimed at establishing the effects of the agglomerates on active ingredient release profiles. A model substance, caffeine, was tested in the powdered form and in the two agglomerated forms prepared by wet granulation and compaction. The profiles of caffeine release from these forms were measured using a flow-through cell dissolution apparatus (USP 4) in an open-loop arrangement. To identify the particular processes responsible for the differences in the dissolution profiles of the model forms, we developed a mathematical description of the dissolution profiles. Using this mathematical approach, we proposed that caffeine was adsorbed to the microcrystalline cellulose present in the granulated and compacted form and that diffusion of the active ingredient was inhibited in the presence of a binder in the granulate. Both of these effects resulted in imperfections in the shape of dissolution profiles and in a decrease in the dissolution rate of caffeine. The mathematical model is based on generic parameters, thus it is transferable to other pharmaceutical substances in powdered and agglomerated forms.
dcterms:title
Analysis of Drug Release from Different Agglomerates Using a Mathematical Model Analysis of Drug Release from Different Agglomerates Using a Mathematical Model
skos:prefLabel
Analysis of Drug Release from Different Agglomerates Using a Mathematical Model Analysis of Drug Release from Different Agglomerates Using a Mathematical Model
skos:notation
RIV/60461373:22310/14:43898271!RIV15-MSM-22310___
n3:aktivita
n5:S
n3:aktivity
S
n3:cisloPeriodika
4
n3:dodaniDat
n17:2015
n3:domaciTvurceVysledku
n11:4811569 n11:9396233
n3:druhVysledku
n9:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
2655
n3:idVysledku
RIV/60461373:22310/14:43898271
n3:jazykVysledku
n12:eng
n3:klicovaSlova
compaction; high-shear wet granulation; agglomerate; mathematical modeling; release rate; Dissolution
n3:klicoveSlovo
n8:mathematical%20modeling n8:high-shear%20wet%20granulation n8:agglomerate n8:release%20rate n8:compaction n8:Dissolution
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[979381EAB3B6]
n3:nazevZdroje
Dissolution Technologies
n3:obor
n10:CI
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n17:2014
n3:svazekPeriodika
21
n3:tvurceVysledku
Petrů, Jiří Zámostný, Petr
n3:wos
000347437200004
s:issn
1521-298X
s:numberOfPages
8
n6:doi
10.14227/DT210414P40
n15:organizacniJednotka
22310