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Statements

Subject Item
n2:RIV%2F60461373%3A22310%2F13%3A43891662%21RIV14-MSM-22310___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Metabolism of benzene, an important environmental and industrial carcinogen, produces three electrophilic intermediates, namely, benzene oxide (BO), 1,2- and 1,4-benzoquinone (1,2-BQ and 1,4-BQ). Numerous DNA adducts formed by these metabolites in vitro have been reported in the literature but only one of them was hitherto identified in vivo. In a search for urinary DNA adducts specific LC-ESI-MS methods have been developed for determination in urine of six nucleobase adducts Mice were exposed to benzene vapours at concentrations of 900 and 1800 mg/m3, 6 h/day for 15 consecutive days. The only adduct detected in their urine was DHPA. It was found in 8 out of total 30 urine samples from the high exposure group at concentrations of 352 +/- 146 pg/ml, whereas urines from the low exposure were negative. Conversion of benzene to DHPA was estimated to 2.2 x 10-6 % of the absorbed dose. In conclusion, DHPA is an easily depurinating adduct thus allowing indication of only high recent exposure to benzene, but not long-term damage to DNA in tissues. Metabolism of benzene, an important environmental and industrial carcinogen, produces three electrophilic intermediates, namely, benzene oxide (BO), 1,2- and 1,4-benzoquinone (1,2-BQ and 1,4-BQ). Numerous DNA adducts formed by these metabolites in vitro have been reported in the literature but only one of them was hitherto identified in vivo. In a search for urinary DNA adducts specific LC-ESI-MS methods have been developed for determination in urine of six nucleobase adducts Mice were exposed to benzene vapours at concentrations of 900 and 1800 mg/m3, 6 h/day for 15 consecutive days. The only adduct detected in their urine was DHPA. It was found in 8 out of total 30 urine samples from the high exposure group at concentrations of 352 +/- 146 pg/ml, whereas urines from the low exposure were negative. Conversion of benzene to DHPA was estimated to 2.2 x 10-6 % of the absorbed dose. In conclusion, DHPA is an easily depurinating adduct thus allowing indication of only high recent exposure to benzene, but not long-term damage to DNA in tissues.
dcterms:title
3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene 3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene
skos:prefLabel
3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene 3-(3,4-Dihydroxyphenyl)adenine, a Urinary DNA Adduct Formed in Mice Exposed to High Concentrations of Benzene
skos:notation
RIV/60461373:22310/13:43891662!RIV14-MSM-22310___
n14:predkladatel
n15:orjk%3A22310
n5:aktivita
n7:Z n7:P
n5:aktivity
P(2B08051), P(LC06070), Z(MSM6046137301)
n5:cisloPeriodika
6
n5:dodaniDat
n8:2014
n5:domaciTvurceVysledku
n10:3663590 n10:3414876 n10:9575618
n5:druhVysledku
n18:J
n5:duvernostUdaju
n21:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
119832
n5:idVysledku
RIV/60461373:22310/13:43891662
n5:jazykVysledku
n12:eng
n5:klicovaSlova
N3-Adenine adducts; Metabolism; DNA adducts; Benzoquinones; Benzene oxide; Benzene
n5:klicoveSlovo
n6:N3-Adenine%20adducts n6:Metabolism n6:Benzene n6:DNA%20adducts n6:Benzoquinones n6:Benzene%20oxide
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[E4721A2FAD75]
n5:nazevZdroje
Journal of Applied Toxicology
n5:obor
n20:CB
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
7
n5:projekt
n16:LC06070 n16:2B08051
n5:rokUplatneniVysledku
n8:2013
n5:svazekPeriodika
33
n5:tvurceVysledku
Krouželka, Jan Mikeš, Petr Frantík, Emil Šístek, Václav Králík, Antonín Linhart, Igor Mráz, Jaroslav
n5:wos
000318112500016
n5:zamer
n13:MSM6046137301
s:issn
0260-437X
s:numberOfPages
5
n3:doi
10.1002/jat.2716
n19:organizacniJednotka
22310