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Statements

Subject Item
n2:RIV%2F60461373%3A22310%2F08%3A00020022%21RIV09-MSM-22310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
3-(2-Hydroxy-2-phenylethyl)- and 3-(2-hydroxy-1-phenylethyl)adenine, DNA adducts derived from styrene, along with their 9-substituted analogues were prepared by alkylation of 8-bromoadenine with corresponding allyl-protected bromohydrins followed by a new deallylation procedure using tetrakis(triphenylphosphine)palladium catalyzed reductive cleavage by poly(methylhydrosiloxane) in the presence of p-toluenesulphonic acid. This novel procedure proved to be useful for purine derivatives, which were resistant to other deallylation protocols. Structure of positional isomers was assigned using 2D NMR experiments HMBC and HMQC. 3-(2-Hydroxy-2-phenylethyl)- and 3-(2-hydroxy-1-phenylethyl)adenine, DNA adducts derived from styrene, along with their 9-substituted analogues were prepared by alkylation of 8-bromoadenine with corresponding allyl-protected bromohydrins followed by a new deallylation procedure using tetrakis(triphenylphosphine)palladium catalyzed reductive cleavage by poly(methylhydrosiloxane) in the presence of p-toluenesulphonic acid. This novel procedure proved to be useful for purine derivatives, which were resistant to other deallylation protocols. Structure of positional isomers was assigned using 2D NMR experiments HMBC and HMQC. 3-(1-Fenyl-2-hydroxyethyl)- a 3-(2-fenyl-2-hydroxyethyl)adenin byly připraveny spolu s příslušnými 9-substituovanými adeniny alkylací 8-bromadeninu s následnou debromací a odchráněným. Připravené 3-substituované adeniny jsou pravděpodobnými DNA adukty odvozenými od styrenu a budou použity jako analytické standardy pro vývoj metod biologického monitorování exposice styrenu.
dcterms:title
Syntéza 3-(1-fenyl-2-hydroxyethyl)- a 3-(2-fenyl-2-hydroxyethyl)adeninu, DNA aduktů odvozených od styrenu Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene
skos:prefLabel
Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene Syntéza 3-(1-fenyl-2-hydroxyethyl)- a 3-(2-fenyl-2-hydroxyethyl)adeninu, DNA aduktů odvozených od styrenu
skos:notation
RIV/60461373:22310/08:00020022!RIV09-MSM-22310___
n3:aktivita
n17:P n17:Z
n3:aktivity
P(GA203/06/0888), P(LC06070), Z(MSM6046137301)
n3:cisloPeriodika
May-June
n3:dodaniDat
n11:2009
n3:domaciTvurceVysledku
n7:9575618 n7:3414876 n7:6702198
n3:druhVysledku
n15:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
398808
n3:idVysledku
RIV/60461373:22310/08:00020022
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Alkylation of purines; 3-Alykladenines; DNA adducts; styrene
n3:klicoveSlovo
n8:styrene n8:DNA%20adducts n8:3-Alykladenines n8:Alkylation%20of%20purines
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[FD6F52556441]
n3:nazevZdroje
Journal of Heterocyclic Chemistry
n3:obor
n14:CC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n4:GA203%2F06%2F0888 n4:LC06070
n3:rokUplatneniVysledku
n11:2008
n3:svazekPeriodika
45
n3:tvurceVysledku
Krouželka, Jan Tobrman, Tomáš Linhart, Igor
n3:wos
000255967700025
n3:zamer
n9:MSM6046137301
s:issn
0022-152X
s:numberOfPages
7
n16:organizacniJednotka
22310