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Statements

Subject Item
n2:RIV%2F60461373%3A22310%2F04%3A00020154%21RIV09-GA0-22310___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy There were synthesized three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridinium iodide 3c. Their reactivation potency was examined using standard in vitro reactivation test. As the source of acetylcholinesterase was used rat brain homogenate. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivator were worse acetylcholinesterase reactivators in regard to 2-PAM. In this paper we have also tested reactivation potency of the oxime 2-PAM against inhibition acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are shown only by reactivation sarin- and VX-inhibited acetylcholinesterase. There were synthesized three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridinium iodide 3c. Their reactivation potency was examined using standard in vitro reactivation test. As the source of acetylcholinesterase was used rat brain homogenate. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivator were worse acetylcholinesterase reactivators in regard to 2-PAM. In this paper we have also tested reactivation potency of the oxime 2-PAM against inhibition acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are shown only by reactivation sarin- and VX-inhibited acetylcholinesterase.
dcterms:title
Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents
skos:prefLabel
Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy
skos:notation
RIV/60461373:22310/04:00020154!RIV09-GA0-22310___
n4:aktivita
n15:P
n4:aktivity
P(GA203/01/1093), P(ONVLAJEP20031)
n4:cisloPeriodika
10
n4:dodaniDat
n12:2009
n4:domaciTvurceVysledku
n7:5612640 n7:1606778
n4:druhVysledku
n17:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
589370
n4:idVysledku
RIV/60461373:22310/04:00020154
n4:jazykVysledku
n8:eng
n4:klicovaSlova
VX; reactivation; acetylcholinesterase; oximes; sarin; tabun; cyclosarin
n4:klicoveSlovo
n5:cyclosarin n5:reactivation n5:sarin n5:VX n5:acetylcholinesterase n5:tabun n5:oximes
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[DA1CCC33EB84]
n4:nazevZdroje
Journal of Applied Biomedicine
n4:obor
n9:CC
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
4
n4:projekt
n16:ONVLAJEP20031 n16:GA203%2F01%2F1093
n4:rokUplatneniVysledku
n12:2004
n4:svazekPeriodika
2
n4:tvurceVysledku
Cabal, Jiří Kuča, Kamil. Pícha, Jan Liška, František
s:issn
1214-021X
s:numberOfPages
6
n11:organizacniJednotka
22310