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Statements

Subject Item
n2:RIV%2F60461373%3A22310%2F04%3A00011790%21RIV%2F2005%2FMSM%2F223105%2FN
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Design, syntéza a studium modelu fotolyasy Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2 are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition. Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2 are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition.
dcterms:title
Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model Design, syntéza a studium modelu fotolyasy
skos:prefLabel
Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model Design, syntéza a studium modelu fotolyasy
skos:notation
RIV/60461373:22310/04:00011790!RIV/2005/MSM/223105/N
n4:strany
8183-8185
n4:aktivita
n18:Z
n4:aktivity
Z(MSM 223100001)
n4:cisloPeriodika
24
n4:dodaniDat
n5:2005
n4:domaciTvurceVysledku
n8:6624707
n4:druhVysledku
n7:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
559905
n4:idVysledku
RIV/60461373:22310/04:00011790
n4:jazykVysledku
n10:eng
n4:klicovaSlova
Photolyase;enzyme models;flavin
n4:klicoveSlovo
n6:Photolyase n6:enzyme%20models n6:flavin
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[44E8B7A0A7A5]
n4:nazevZdroje
Journal of Organic Chemistry
n4:obor
n14:CC
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n5:2004
n4:svazekPeriodika
69
n4:tvurceVysledku
Sax, M. Saettel, N. Wiest, O. König, B. Cibulka, Radek Harrison, C.
n4:zamer
n11:MSM%20223100001
s:issn
0022-3263
s:numberOfPages
3
n13:organizacniJednotka
22310