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Statements

Subject Item
n2:RIV%2F60461373%3A22310%2F03%3A00008311%21RIV%2F2004%2FGA0%2F223104%2FN
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Halogen-metal exchange reaction of 9-benzyl-6-iodopurine with iPrMgCl in toluene at -80 degreesC proceeds almost quantitatively. Such a purine-derived Grignard reagent reacts selectively with aldehydes in toluene, giving the corresponding alcohols in 25-62% yield, while other functional groups such as ketones, esters, and nitriles do not react under these conditions. The reaction can be extended to protected 6-iodopurine ribonucleoside. Halogen-metal exchange reaction of 9-benzyl-6-iodopurine with iPrMgCl in toluene at -80 degreesC proceeds almost quantitatively. Such a purine-derived Grignard reagent reacts selectively with aldehydes in toluene, giving the corresponding alcohols in 25-62% yield, while other functional groups such as ketones, esters, and nitriles do not react under these conditions. The reaction can be extended to protected 6-iodopurine ribonucleoside.
dcterms:title
6-Magnesiated Purines: Preparation and Reaction with Aldehydes 6-Magnesiated Purines: Preparation and Reaction with Aldehydes
skos:prefLabel
6-Magnesiated Purines: Preparation and Reaction with Aldehydes 6-Magnesiated Purines: Preparation and Reaction with Aldehydes
skos:notation
RIV/60461373:22310/03:00008311!RIV/2004/GA0/223104/N
n3:strany
4289-4291
n3:aktivita
n12:P
n3:aktivity
P(GA203/03/0035)
n3:cisloPeriodika
23
n3:dodaniDat
n5:2004
n3:domaciTvurceVysledku
n4:5078008 n4:6702198
n3:druhVysledku
n9:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
636887
n3:idVysledku
RIV/60461373:22310/03:00008311
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Adenosine-deaminase; cytostatic activity; nucleosides; lithiation; reagents; analogs; bases
n3:klicoveSlovo
n7:reagents n7:nucleosides n7:bases n7:cytostatic%20activity n7:analogs n7:Adenosine-deaminase n7:lithiation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[F8AE659065C0]
n3:nazevZdroje
Organic Letters
n3:obor
n8:CC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n15:GA203%2F03%2F0035
n3:rokUplatneniVysledku
n5:2003
n3:svazekPeriodika
5
n3:tvurceVysledku
Dvořák, Dalimil Tobrman, Tomáš
s:issn
1523-7060
s:numberOfPages
3
n18:organizacniJednotka
22310