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Statements

Subject Item
n2:RIV%2F60461373%3A22310%2F01%3A00004353%21RIV%2F2004%2FMSM%2F223104%2FN
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Metabolism of styrene, an important industrial monomer, is reviewed. The attention is focused on the stereoselectivity of its oxidation to 7,8-styrene oxide as well as on further stereoselective biotransformation by hydrolytic and mercapturic acid pathway. Toxic effects such as mutagenicity, genotoxicity, hepatotoxicity, and pneumotoxicity may be related to the ratio of styrene oxide enantiomers at the target site. In rats formation of the less mutagenic (S)-styrene oxide and a faster detoxication of the (R)-enantiomer is favored. In mice metabolic activation of styrene favors the formation of (R)-styrene oxide but this more toxic enantiomer is detoxified faster, so that a nearly racemic styrene oxide results. Stereochemistry Metabolism of styrene, an important industrial monomer, is reviewed. The attention is focused on the stereoselectivity of its oxidation to 7,8-styrene oxide as well as on further stereoselective biotransformation by hydrolytic and mercapturic acid pathway. Toxic effects such as mutagenicity, genotoxicity, hepatotoxicity, and pneumotoxicity may be related to the ratio of styrene oxide enantiomers at the target site. In rats formation of the less mutagenic (S)-styrene oxide and a faster detoxication of the (R)-enantiomer is favored. In mice metabolic activation of styrene favors the formation of (R)-styrene oxide but this more toxic enantiomer is detoxified faster, so that a nearly racemic styrene oxide results. Stereochemistry
dcterms:title
Stereochemistry od styrene biotransformation Stereochemistry od styrene biotransformation
skos:prefLabel
Stereochemistry od styrene biotransformation Stereochemistry od styrene biotransformation
skos:notation
RIV/60461373:22310/01:00004353!RIV/2004/MSM/223104/N
n3:strany
353-368
n3:aktivita
n18:Z
n3:aktivity
Z(MSM 223100001)
n3:cisloPeriodika
3-4
n3:dodaniDat
n14:2004
n3:domaciTvurceVysledku
n9:9575618
n3:druhVysledku
n16:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
697240
n3:idVysledku
RIV/60461373:22310/01:00004353
n3:jazykVysledku
n11:eng
n3:klicovaSlova
styren; enantiomery styren-7,8-oxideu; stereoselektivita biotransformace; merkapturové kyseliny; toxicita.
n3:klicoveSlovo
n5:merkapturov%C3%A9%20kyseliny n5:8-oxideu n5:styren n5:enantiomery%20styren-7 n5:toxicita. n5:stereoselektivita%20biotransformace
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[D8A01AF97C6B]
n3:nazevZdroje
Drug Metabolism Reviews
n3:obor
n17:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n14:2001
n3:svazekPeriodika
33
n3:tvurceVysledku
Linhart, Igor
n3:zamer
n13:MSM%20223100001
s:issn
0360-2532
s:numberOfPages
16
n15:organizacniJednotka
22310