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Statements

Subject Item
n2:RIV%2F60460709%3A41610%2F10%3A22330%21RIV13-MZE-41610___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
In total, 26 natural compounds of various chemical classes (flavonoids, alkaloids, terpenoids) and 19 crude extracts from selected plants were tested in vitro for antibacterial activity against three strains of P. larvae, the causal agent of American Foulbrood Disease of honey bees (AFB) by the broth microdilution method. Among the individual substances, sanguinarine (MIC 4µg/ml), followed by thymoquinone, capsaicin, trans-2-hexenal and nordihydroguaiaretic acid (MIC 4-32µg/ml) possessed the strongest antibacterial effect. In case of extracts, common hop (Humulus lupulus L.) and myrtle (Myrtus communis L.) methanolic-dichloromethane extracts exhibited the highest growth-inhibitory effect with MICs ranging from 2 to 8µg/ml. Acute oral toxicity of the most active natural products was determined on adult honey bees, showing them as non-toxic at concentrations as high as 100µg peer bee. Our study leads to identification of highly potent natural products effective against AFB in vitro with very low MICs c In total, 26 natural compounds of various chemical classes (flavonoids, alkaloids, terpenoids) and 19 crude extracts from selected plants were tested in vitro for antibacterial activity against three strains of P. larvae, the causal agent of American Foulbrood Disease of honey bees (AFB) by the broth microdilution method. Among the individual substances, sanguinarine (MIC 4µg/ml), followed by thymoquinone, capsaicin, trans-2-hexenal and nordihydroguaiaretic acid (MIC 4-32µg/ml) possessed the strongest antibacterial effect. In case of extracts, common hop (Humulus lupulus L.) and myrtle (Myrtus communis L.) methanolic-dichloromethane extracts exhibited the highest growth-inhibitory effect with MICs ranging from 2 to 8µg/ml. Acute oral toxicity of the most active natural products was determined on adult honey bees, showing them as non-toxic at concentrations as high as 100µg peer bee. Our study leads to identification of highly potent natural products effective against AFB in vitro with very low MICs c
dcterms:title
In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees
skos:prefLabel
In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees In vitro growth-inhibitory effect of plant-derived extracts and compounds against Paenibacillus larvae and their acute oral toxicity to adult honey bees
skos:notation
RIV/60460709:41610/10:22330!RIV13-MZE-41610___
n3:aktivita
n15:P n15:Z
n3:aktivity
P(GD525/08/H060), P(QH72144), Z(MSM6046070901)
n3:cisloPeriodika
1-2
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n7:6775861 n7:9976299 n7:2856018
n3:druhVysledku
n13:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
263293
n3:idVysledku
RIV/60460709:41610/10:22330
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Antimicrobial activity, Apis mellifera, Honey bee, Humulus lupulus, Myrtus communis, Paenibacillus larvae, Thymoquinone, Toxicity
n3:klicoveSlovo
n4:Humulus%20lupulus n4:Toxicity n4:Paenibacillus%20larvae n4:Apis%20mellifera n4:Myrtus%20communis n4:Honey%20bee n4:Thymoquinone n4:Antimicrobial%20activity
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[1647862A51D9]
n3:nazevZdroje
Veterinary Microbiology
n3:obor
n18:GH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:projekt
n11:GD525%2F08%2FH060 n11:QH72144
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
145
n3:tvurceVysledku
Titěra, Dalibor Flesar, Jaroslav Klouček, Pavel Rada, Vojtěch Kokoška, Ladislav Havlík, Jaroslav Stropnický, Michal Bednář, Michal
n3:zamer
n14:MSM6046070901
s:issn
0378-1135
s:numberOfPages
5
n10:organizacniJednotka
41610