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Statements

Subject Item
n2:RIV%2F60460709%3A41210%2F13%3A60405%21RIV14-MSM-41210___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we tested the effect of antibiotics on the reproductive parameters of mice males during puberty with the therapeutic dose used in humans, and with lower and higher doses. The outbred mouse strain CD1 with higher heterozygosity was exposed for 14 days at puberty. Adult males at the age of 70 days were used for the measurements. We observed a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of sperm positively stained with Annexin V and TUNEL and a lower number of acrosome-intact sperm was detected. In conclusion, the treatment of male mice with antibiotics in puberty led to long-lasting effects on reproductive organs and spermatoz Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we tested the effect of antibiotics on the reproductive parameters of mice males during puberty with the therapeutic dose used in humans, and with lower and higher doses. The outbred mouse strain CD1 with higher heterozygosity was exposed for 14 days at puberty. Adult males at the age of 70 days were used for the measurements. We observed a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of sperm positively stained with Annexin V and TUNEL and a lower number of acrosome-intact sperm was detected. In conclusion, the treatment of male mice with antibiotics in puberty led to long-lasting effects on reproductive organs and spermatoz
dcterms:title
Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice
skos:prefLabel
Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice
skos:notation
RIV/60460709:41210/13:60405!RIV14-MSM-41210___
n12:predkladatel
n16:orjk%3A41210
n5:aktivita
n11:Z n11:S n11:P
n5:aktivity
P(1M06011), P(GA523/09/1793), P(GAP503/12/1834), S, Z(AV0Z50520701)
n5:cisloPeriodika
6
n5:dodaniDat
n13:2014
n5:domaciTvurceVysledku
n14:4064135 n14:3761207
n5:druhVysledku
n19:J
n5:duvernostUdaju
n9:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
59664
n5:idVysledku
RIV/60460709:41210/13:60405
n5:jazykVysledku
n15:eng
n5:klicovaSlova
Tetracycline, Doxycycline, Testes, Sperm, Apoptosis, Puberty
n5:klicoveSlovo
n6:Apoptosis n6:Puberty n6:Sperm n6:Tetracycline n6:Testes n6:Doxycycline
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[032703AAE781]
n5:nazevZdroje
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
n5:obor
n7:EA
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
8
n5:projekt
n10:GA523%2F09%2F1793 n10:1M06011 n10:GAP503%2F12%2F1834
n5:rokUplatneniVysledku
n13:2013
n5:svazekPeriodika
65
n5:tvurceVysledku
Dorosh, Andriy Pěknicová, Jana Kubátová, Alena Děd, Lukáš Rajmon, Radko Margaryan, Hasmik Elzeinová, Fatima Makovický, Peter
n5:wos
000322929800024
n5:zamer
n20:AV0Z50520701
s:issn
0940-2993
s:numberOfPages
7
n18:organizacniJednotka
41210