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Statements

Subject Item
n2:RIV%2F60460709%3A41210%2F13%3A60053%21RIV14-MSM-41210___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Quinones are compounds frequently contained in medicinal plants used for the treatment of inflammatory diseases. Therefore, the impact of plant-derived quinones on the arachidonic acid metabolic pathway is worthy of investigation. In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B-4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. The benzoquinones primin (3) and thymohydroquinone (4) (IC50 = 4.0 and 4.1 mu M, respectively) showed activity comparable with the reference inhibitor zileuton (IC50 = 4.1 mu M). Moderate activity was observed for the benzoquinone thymoquinone (2) (IC50 = 18.2 mu M) and the naphthoquinone shikonin (1) (IC50 = 24.3 mu M). The anthraquinone emodin and the naphthoquinone plumbagin (5) displayed only weak activities (IC50 > 50 mu M). The binding modes of the active compounds were further evaluated in silico by molecular docking to the human 5-LOX crys Quinones are compounds frequently contained in medicinal plants used for the treatment of inflammatory diseases. Therefore, the impact of plant-derived quinones on the arachidonic acid metabolic pathway is worthy of investigation. In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B-4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. The benzoquinones primin (3) and thymohydroquinone (4) (IC50 = 4.0 and 4.1 mu M, respectively) showed activity comparable with the reference inhibitor zileuton (IC50 = 4.1 mu M). Moderate activity was observed for the benzoquinone thymoquinone (2) (IC50 = 18.2 mu M) and the naphthoquinone shikonin (1) (IC50 = 24.3 mu M). The anthraquinone emodin and the naphthoquinone plumbagin (5) displayed only weak activities (IC50 > 50 mu M). The binding modes of the active compounds were further evaluated in silico by molecular docking to the human 5-LOX crys
dcterms:title
Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones
skos:prefLabel
Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones
skos:notation
RIV/60460709:41210/13:60053!RIV14-MSM-41210___
n15:predkladatel
n19:orjk%3A41210
n3:aktivita
n10:I n10:S n10:P n10:Z
n3:aktivity
I, P(GP525/09/P528), P(MEB061112), S, Z(AV0Z50380511)
n3:cisloPeriodika
1
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
n13:3992020
n3:druhVysledku
n9:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
80210
n3:idVysledku
RIV/60460709:41210/13:60053
n3:jazykVysledku
n16:eng
n3:klicovaSlova
5-Lipoxygenase, Anti-inflammatory activity, Dual COX/LOX inhibition, Natural compounds, Molecular docking
n3:klicoveSlovo
n11:Dual%20COX%2FLOX%20inhibition n11:Anti-inflammatory%20activity n11:Natural%20compounds n11:5-Lipoxygenase n11:Molecular%20docking
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[F39A27872A41]
n3:nazevZdroje
Natural Product Communications
n3:obor
n20:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
12
n3:projekt
n17:GP525%2F09%2FP528 n17:MEB061112
n3:rokUplatneniVysledku
n12:2013
n3:svazekPeriodika
8
n3:tvurceVysledku
Dvořáková, Marcela Vaněk, Tomáš Přibylová, Marie Malík, Jan Temml, Veronika Bauer, Rudolf Kokoška, Ladislav Kutil, Zsófia Widowitz, Ute Landa, Přemysl Schuster, Daniela Maršík, Petr
n3:wos
000314617200027
n3:zamer
n18:AV0Z50380511
s:issn
1934-578X
s:numberOfPages
4
n5:organizacniJednotka
41210