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Statements

Subject Item
n2:RIV%2F60460709%3A41210%2F09%3A31060%21RIV13-MZE-41210___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
After reaching metaphase II, in vitro matured oocytes undergo the complex processes referred to as oocyte aging. Under our culture conditions, some aged oocytes remained at the stage of metaphase II, some underwent spontaneous parthenogenetic activation and others underwent cellular death, either through apoptosis (fragmentation) or lysis. We investigated the effect of c-Jun N-terminal kinases (JNK) and p38 Mitogen-activated protein kinase (p38 MAPK) inhibition on pig oocyte aging and the activity of JNK and p38 MAPK during the aging period. Inhibition of JNK protected the oocytes from fragmentation (0% fragmented oocytes under JNK inhibition vs. 26% fragmented oocytes in the control group). Inhibition of p38 MAPK had no effect on fragmentation. Inhibition of JNK also had an influence on spontaneous parthenogenetic activation of aged oocytes. The ratio of activated JNK to total JNK decreased during aging of oocytes. However, exit from MII had no effect on it. The ratio of activated p38 MAPK to total After reaching metaphase II, in vitro matured oocytes undergo the complex processes referred to as oocyte aging. Under our culture conditions, some aged oocytes remained at the stage of metaphase II, some underwent spontaneous parthenogenetic activation and others underwent cellular death, either through apoptosis (fragmentation) or lysis. We investigated the effect of c-Jun N-terminal kinases (JNK) and p38 Mitogen-activated protein kinase (p38 MAPK) inhibition on pig oocyte aging and the activity of JNK and p38 MAPK during the aging period. Inhibition of JNK protected the oocytes from fragmentation (0% fragmented oocytes under JNK inhibition vs. 26% fragmented oocytes in the control group). Inhibition of p38 MAPK had no effect on fragmentation. Inhibition of JNK also had an influence on spontaneous parthenogenetic activation of aged oocytes. The ratio of activated JNK to total JNK decreased during aging of oocytes. However, exit from MII had no effect on it. The ratio of activated p38 MAPK to total
dcterms:title
The roles of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) in aged pig oocytes The roles of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) in aged pig oocytes
skos:prefLabel
The roles of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) in aged pig oocytes The roles of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) in aged pig oocytes
skos:notation
RIV/60460709:41210/09:31060!RIV13-MZE-41210___
n3:aktivita
n15:Z n15:P
n3:aktivity
P(GD523/08/H064), P(QG50052), Z(MSM6046070901), Z(MZE0002701401)
n3:cisloPeriodika
1
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n10:8783004 n10:4182944 n10:5490375 n10:7478607 n10:1500015 n10:3761207
n3:druhVysledku
n19:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
339801
n3:idVysledku
RIV/60460709:41210/09:31060
n3:jazykVysledku
n4:eng
n3:klicovaSlova
aging, JNK, p38 MAPK, oocyte, pig
n3:klicoveSlovo
n6:pig n6:JNK n6:p38%20MAPK n6:aging n6:oocyte
n3:kodStatuVydavatele
JP - Japonsko
n3:kontrolniKodProRIV
[011B8EF3EBF6]
n3:nazevZdroje
Journal of Reproduction and Development
n3:obor
n9:GG
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
10
n3:projekt
n8:GD523%2F08%2FH064 n8:QG50052
n3:rokUplatneniVysledku
n12:2009
n3:svazekPeriodika
55
n3:tvurceVysledku
Jílek, František Chmelíková, Eva Petrová, I. Petr, Jaroslav Dörflerová (Čtrnáctá), Andrea Vodková, Zuzana Řehák, D. Pytloun, P. Rajmon, Radko Sedmíková, Markéta
n3:zamer
n11:MSM6046070901 n11:MZE0002701401
s:issn
0916-8818
s:numberOfPages
8
n18:organizacniJednotka
41210