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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F14%3A43875235%21RIV15-MO0-G44_____
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://obd3.hk.pmfhk.cz/fcgi/verso.fpl/_TS_/1429604803/dload/3017574/2014_Invitro_MMSL_Kukla.PDF
dcterms:description
The genus Enterococcus is represented by some of the clinically important species and is well known for its antibiotic resistance, which participates in colonization and infection. Increasing resistance of enterococci has been evoked due to the excessive use of antibotics not merely for therapeutic purposes or indicated cases. One of the promising possibilities how to reduce the use of great amount of antibiotics is to utilize antimicrobial properties of natural substances. Usnic acid is a lichem compound possessing antibacterial activity against gramůpositive bacteria including enterococci. Octyl gallate, gallic acid ester, has significant antibacterial and antifungal properties. This study was focused on the evaluation of resistant enterococci susceptibility to usnic acid and octyl gallate in comparison with control group of enterococci. Antibacterial activity of usnic acid and octyl gallate was defined as minimum inhibitory concentration and minum bactericidal concentration,. Usnic acid inhibited all tested enerococci in concentration range 4.7-37.5 mg.L-1. MIC values of octyl gallate for all tested enterococci ranged between 37.5-150 mg.L-1. In contrast to octyl gallate, bactericidal activity of usnic acid was not confirmed. Antibacterial activities of tested compounds were almost equal among resistant enterococci and control group of enterococci exibiting great potential of usnic acid and octyl gallate for tretment of enterococcal infections. The genus Enterococcus is represented by some of the clinically important species and is well known for its antibiotic resistance, which participates in colonization and infection. Increasing resistance of enterococci has been evoked due to the excessive use of antibotics not merely for therapeutic purposes or indicated cases. One of the promising possibilities how to reduce the use of great amount of antibiotics is to utilize antimicrobial properties of natural substances. Usnic acid is a lichem compound possessing antibacterial activity against gramůpositive bacteria including enterococci. Octyl gallate, gallic acid ester, has significant antibacterial and antifungal properties. This study was focused on the evaluation of resistant enterococci susceptibility to usnic acid and octyl gallate in comparison with control group of enterococci. Antibacterial activity of usnic acid and octyl gallate was defined as minimum inhibitory concentration and minum bactericidal concentration,. Usnic acid inhibited all tested enerococci in concentration range 4.7-37.5 mg.L-1. MIC values of octyl gallate for all tested enterococci ranged between 37.5-150 mg.L-1. In contrast to octyl gallate, bactericidal activity of usnic acid was not confirmed. Antibacterial activities of tested compounds were almost equal among resistant enterococci and control group of enterococci exibiting great potential of usnic acid and octyl gallate for tretment of enterococcal infections.
dcterms:title
In vitro antibacterial activity of usnic acid and octyl gallate against resistant enterococcus strains In vitro antibacterial activity of usnic acid and octyl gallate against resistant enterococcus strains
skos:prefLabel
In vitro antibacterial activity of usnic acid and octyl gallate against resistant enterococcus strains In vitro antibacterial activity of usnic acid and octyl gallate against resistant enterococcus strains
skos:notation
RIV/60162694:G44__/14:43875235!RIV15-MO0-G44_____
n3:aktivita
n6:V n6:S n6:P
n3:aktivity
P(QI111A166), S, V
n3:cisloPeriodika
3
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n13:4888162 n13:3986152
n3:druhVysledku
n18:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
21066
n3:idVysledku
RIV/60162694:G44__/14:43875235
n3:jazykVysledku
n15:eng
n3:klicovaSlova
MBC; MIC; usnic acid; octyl gallate; enterococci
n3:klicoveSlovo
n14:usnic%20acid n14:octyl%20gallate n14:MIC n14:enterococci n14:MBC
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[366BFDFDDA0F]
n3:nazevZdroje
Military Medical Science Letters
n3:obor
n11:FN
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n19:QI111A166
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
83
n3:tvurceVysledku
Boštíková, Vanda Adámková, Vaclava Slehová, Eva Janovska, Sylva Mazurová, Jaroslava Kukla, Rudolf Sleha, Radek
s:issn
0372-7025
s:numberOfPages
10
n17:organizacniJednotka
G44