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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F14%3A43875219%21RIV15-MSM-G44_____
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://www.nel.edu/archive_issues/o/35_s2/35_s2_Pohanka_155-157.pdf
dcterms:description
OBJECTIVES: HI-6 or asoxime in some sources is an antidotum for nerve agents. In recent experiments, implication of HI-6 in immunity response was proved; however, the issue was not studied in details. In this experiment, role of cytokines in HI-6 impact on immunity was searched. DESIGN: BALB/c mice were exposed to saline, HI-6 in a dose 1 - 100 mg/kg and/or 1 keyhole limpet hemocyanin (KLH) 1 mg/kg. Mice were sacrificed 21 days after experiment beginning and interleukins (IL) 1, 2, 4, 6 were determined by Enzyme Linked Immunosorbent Assay (ELISA). RESULTS: The animals had no pathological manifestation. From the tested cytokines, no significant alteration was found for the IL-1, IL-4 and IL-6. IL-2 was significantly increased in a dose response manner. CONCLUSIONS: The experimental data well correlates with the previous work where HI-6 caused increase of antibodies production. HI-6 is suitable to be used as an adjuvant whenever immunity should be pharmacologically altered. OBJECTIVES: HI-6 or asoxime in some sources is an antidotum for nerve agents. In recent experiments, implication of HI-6 in immunity response was proved; however, the issue was not studied in details. In this experiment, role of cytokines in HI-6 impact on immunity was searched. DESIGN: BALB/c mice were exposed to saline, HI-6 in a dose 1 - 100 mg/kg and/or 1 keyhole limpet hemocyanin (KLH) 1 mg/kg. Mice were sacrificed 21 days after experiment beginning and interleukins (IL) 1, 2, 4, 6 were determined by Enzyme Linked Immunosorbent Assay (ELISA). RESULTS: The animals had no pathological manifestation. From the tested cytokines, no significant alteration was found for the IL-1, IL-4 and IL-6. IL-2 was significantly increased in a dose response manner. CONCLUSIONS: The experimental data well correlates with the previous work where HI-6 caused increase of antibodies production. HI-6 is suitable to be used as an adjuvant whenever immunity should be pharmacologically altered.
dcterms:title
Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model
skos:prefLabel
Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model
skos:notation
RIV/60162694:G44__/14:43875219!RIV15-MSM-G44_____
n3:aktivita
n7:P
n3:aktivity
P(LH11023)
n3:cisloPeriodika
Suppl 2
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n16:3876284
n3:druhVysledku
n4:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
13333
n3:idVysledku
RIV/60162694:G44__/14:43875219
n3:jazykVysledku
n11:eng
n3:klicovaSlova
acetylcholinesterase; cytokine; interleukin; cholinergic anti-inflammatory pathway; vaccination
n3:klicoveSlovo
n9:cytokine n9:vaccination n9:acetylcholinesterase n9:interleukin n9:cholinergic%20anti-inflammatory%20pathway
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[B989E0308BD6]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n8:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n17:LH11023
n3:rokUplatneniVysledku
n13:2014
n3:svazekPeriodika
35
n3:tvurceVysledku
Pohanka, Miroslav
n3:wos
000351064900020
s:issn
0172-780X
s:numberOfPages
3
n19:organizacniJednotka
G44