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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F13%3A43874971%21RIV14-MO0-G44_____
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://academicjournals.org/journal/AJPP/article-abstract/068711B26356
dcterms:description
Obidoxime and asoxime (HI-6) are considered to be the most important acetylcholinesterase (AChE) reactivators applicable for treatment of poisoning by nerve agents. Unfortunately, toxicology of the oximes is not well known. For this reason, we decided to investigate the pertinent adverse effects on guinea pigs which are close to humans in toxicological point of view. HI-6 and obidoxime were administered intramuscularly in 5% of the median lethal dose. The animals were sacrificed 15, 30, 60, 120, and 240 min after exposure, and the brain, liver, spleen and kidneys were collected. Ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), glutathione S-transferase (GST) and glutathione reductase (GR) were measured. Results indicated that obidoxime acted on oxidative stress than HI-6. We found evidence of low molecular weight antioxidants depletion after obidoxime administration. On the other hand, TBARS assay showed significant decrease in brain and little increase in spleen and liver. The effect of HI-6 was more striking than the effect of obidoxime. There was a sign of higher metabolism and production of antioxidants in liver because GR was significantly increased after HI-6 exposure, and it is another sign of ongoing oxidative stress. Owing to the achieved results, obidoxime can be considered as a less toxic drug in counteracting oxidative stress despite its higher toxicity. Obidoxime and asoxime (HI-6) are considered to be the most important acetylcholinesterase (AChE) reactivators applicable for treatment of poisoning by nerve agents. Unfortunately, toxicology of the oximes is not well known. For this reason, we decided to investigate the pertinent adverse effects on guinea pigs which are close to humans in toxicological point of view. HI-6 and obidoxime were administered intramuscularly in 5% of the median lethal dose. The animals were sacrificed 15, 30, 60, 120, and 240 min after exposure, and the brain, liver, spleen and kidneys were collected. Ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), glutathione S-transferase (GST) and glutathione reductase (GR) were measured. Results indicated that obidoxime acted on oxidative stress than HI-6. We found evidence of low molecular weight antioxidants depletion after obidoxime administration. On the other hand, TBARS assay showed significant decrease in brain and little increase in spleen and liver. The effect of HI-6 was more striking than the effect of obidoxime. There was a sign of higher metabolism and production of antioxidants in liver because GR was significantly increased after HI-6 exposure, and it is another sign of ongoing oxidative stress. Owing to the achieved results, obidoxime can be considered as a less toxic drug in counteracting oxidative stress despite its higher toxicity.
dcterms:title
Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety
skos:prefLabel
Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety Antioxidant markers in guinea pig exposed to Obidoxime and HI-6 acetylcholinesterase oxime reactivators containing oxime moiety
skos:notation
RIV/60162694:G44__/13:43874971!RIV14-MO0-G44_____
n3:aktivita
n12:I
n3:aktivity
I
n3:cisloPeriodika
31
n3:dodaniDat
n8:2014
n3:domaciTvurceVysledku
n4:7153082 n4:3876284
n3:druhVysledku
n14:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
61453
n3:idVysledku
RIV/60162694:G44__/13:43874971
n3:jazykVysledku
n9:eng
n3:klicovaSlova
butyrylcholinesterase; acetylcholinesterase; HI-6; obidoxime; Oxidative stress
n3:klicoveSlovo
n5:obidoxime n5:HI-6 n5:acetylcholinesterase n5:Oxidative%20stress n5:butyrylcholinesterase
n3:kodStatuVydavatele
NG - Nigerijská federativní republika
n3:kontrolniKodProRIV
[31D885212E6A]
n3:nazevZdroje
African Journal of Pharmacy and Pharmacology
n3:obor
n19:FP
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n8:2013
n3:svazekPeriodika
7
n3:tvurceVysledku
Drtinová, Lucie Pohanka, Miroslav
s:issn
1996-0816
s:numberOfPages
6
n16:doi
10.5897/AJPP12.438
n7:organizacniJednotka
G44