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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F12%3A43874724%21RIV13-MO0-G44_____
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://mmsl.cz/viCMS/soubory/pdf/MMSL_2012_1_4_WWW.pdf
dcterms:description
Intracellular pathogen F. tularensis is a causative agent of tularemia disease and belongs to the most hazardeous pathogen worldwide, categorized by the Center for Disease Control and Prevention, USA (CDC) as a category A agent. However, no safe and licensed vaccine for revention a F. tularensis infection is available for vaccination. Tularemia is manifested by several forms depending on a route of infection and virulence of a F. tularensis strain. Essential to a development of the disease is the ability to infect, survive and proliferate inside the mononuclear phagocytes, such as macrophages or dendritic cells. Therefore, this review will discuss aspects of F. tularensis intracellular fate within host macrophages, modulate host signaling pathways to benefit Francisella infection and finally, summarize bacterial determinats involved in the process of phagosomal escape and intracellular replication. Intracellular pathogen F. tularensis is a causative agent of tularemia disease and belongs to the most hazardeous pathogen worldwide, categorized by the Center for Disease Control and Prevention, USA (CDC) as a category A agent. However, no safe and licensed vaccine for revention a F. tularensis infection is available for vaccination. Tularemia is manifested by several forms depending on a route of infection and virulence of a F. tularensis strain. Essential to a development of the disease is the ability to infect, survive and proliferate inside the mononuclear phagocytes, such as macrophages or dendritic cells. Therefore, this review will discuss aspects of F. tularensis intracellular fate within host macrophages, modulate host signaling pathways to benefit Francisella infection and finally, summarize bacterial determinats involved in the process of phagosomal escape and intracellular replication.
dcterms:title
Intracellular pathogenesis of Francisella tularensis Intracellular pathogenesis of Francisella tularensis
skos:prefLabel
Intracellular pathogenesis of Francisella tularensis Intracellular pathogenesis of Francisella tularensis
skos:notation
RIV/60162694:G44__/12:43874724!RIV13-MO0-G44_____
n3:aktivita
n18:N
n3:aktivity
N
n3:cisloPeriodika
1
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n8:5863163 n8:6515819
n3:druhVysledku
n16:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
142741
n3:idVysledku
RIV/60162694:G44__/12:43874724
n3:jazykVysledku
n11:eng
n3:klicovaSlova
virulence; Francisella Pathogenicity Island; macrophage; intracellular replication; phagosome; intracellular trafficking; tularemia; Francisella tularensis
n3:klicoveSlovo
n6:phagosome n6:macrophage n6:intracellular%20replication n6:intracellular%20trafficking n6:Francisella%20tularensis n6:virulence n6:tularemia n6:Francisella%20Pathogenicity%20Island
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[A2FAC3631CB0]
n3:nazevZdroje
Military Medical Science Letters
n3:obor
n17:EE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
81
n3:tvurceVysledku
Strašková, Adéla Stulík, Jiří
s:issn
0372-7025
s:numberOfPages
13
n13:organizacniJednotka
G44