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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F12%3A43874619%21RIV13-MO0-G44_____
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Alpha7 nicotinic acetylcholine receptor (alfa7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of alfa7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer's disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of alfa7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer's disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the alfa7 nAChR. Pharmacological, toxicological, and medicinal significance of alfa7 nAChR are discussed throughout this paper. Alpha7 nicotinic acetylcholine receptor (alfa7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of alfa7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer's disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of alfa7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer's disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the alfa7 nAChR. Pharmacological, toxicological, and medicinal significance of alfa7 nAChR are discussed throughout this paper.
dcterms:title
Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology
skos:prefLabel
Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology Alpha 7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology
skos:notation
RIV/60162694:G44__/12:43874619!RIV13-MO0-G44_____
n3:aktivita
n10:I
n3:aktivity
I
n3:cisloPeriodika
2
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n14:3876284
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
121734
n3:idVysledku
RIV/60162694:G44__/12:43874619
n3:jazykVysledku
n8:eng
n3:klicovaSlova
antagonist; agonist; cognitive disorder; Alzheimer's disease; schizophrenia; cholinergic anti-inflammatory pathway; inflammation
n3:klicoveSlovo
n7:cognitive%20disorder n7:Alzheimer%27s%20disease n7:cholinergic%20anti-inflammatory%20pathway n7:agonist n7:inflammation n7:antagonist n7:schizophrenia
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[94D2777EBD3B]
n3:nazevZdroje
International Journal of Molecular Sciences
n3:obor
n18:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
13
n3:tvurceVysledku
Pohanka, Miroslav
n3:wos
000300715700060
s:issn
1661-6596
s:numberOfPages
19
n12:doi
10.3390/ijms13022219
n5:organizacniJednotka
G44