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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F12%3A43874583%21RIV13-MO0-G44_____
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2011.00808.x/full
dcterms:description
The ability of three newly developed reversible inhibitors of acetylcholinesterase (AChE) (K298, K344 and K474) and currently available carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was compared. Neither pyridostigmine nor new reversible inhibitors of AChE were able to increase the LD50 value of soman. Thus, the pharmacological pre-treatment with pyridostigmine or newly synthesized inhibitors of AChE was not able to protect mice against soman-induced lethal acute toxicity. The pharmacological pre-treatment with pyridostigmine alone or with K474 was able to slightly increase the efficacy of antidotal treatment (the oxime HI-6 in combination with atropine) of soman-poisoned mice, but the increase in the efficacy of antidotal treatment was not significant. The other newly developed reversible inhibitors of AChF (K298, K344) were completely ineffective. These findings demonstrate that pharmacological pre-treatment of soman-poisoned mice with tested reversible inhibitors of AChF is not promising. The ability of three newly developed reversible inhibitors of acetylcholinesterase (AChE) (K298, K344 and K474) and currently available carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was compared. Neither pyridostigmine nor new reversible inhibitors of AChE were able to increase the LD50 value of soman. Thus, the pharmacological pre-treatment with pyridostigmine or newly synthesized inhibitors of AChE was not able to protect mice against soman-induced lethal acute toxicity. The pharmacological pre-treatment with pyridostigmine alone or with K474 was able to slightly increase the efficacy of antidotal treatment (the oxime HI-6 in combination with atropine) of soman-poisoned mice, but the increase in the efficacy of antidotal treatment was not significant. The other newly developed reversible inhibitors of AChF (K298, K344) were completely ineffective. These findings demonstrate that pharmacological pre-treatment of soman-poisoned mice with tested reversible inhibitors of AChF is not promising.
dcterms:title
A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice
skos:prefLabel
A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice
skos:notation
RIV/60162694:G44__/12:43874583!RIV13-MO0-G44_____
n3:aktivita
n19:Z
n3:aktivity
Z(MO0FVZ0000501)
n3:cisloPeriodika
4
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n4:6469922 n4:7737076 n4:2182262 n4:7844581
n3:druhVysledku
n8:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
120101
n3:idVysledku
RIV/60162694:G44__/12:43874583
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Rats; Blood; Brain; Bromide; Exposure; Protection; Paraoxonase; Butyrylchololinesterase; Prophylaxis; Oximes
n3:klicoveSlovo
n9:Oximes n9:Bromide n9:Butyrylchololinesterase n9:Rats n9:Exposure n9:Protection n9:Prophylaxis n9:Paraoxonase n9:Brain n9:Blood
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[29158B5074FD]
n3:nazevZdroje
Basic & Clinical Pharmacology & Toxicology
n3:obor
n5:FP
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n7:2012
n3:svazekPeriodika
110
n3:tvurceVysledku
Koomlová, Markéta Musílek, Kamil Bajgar, Jiří Kassa, Jiří
n3:wos
000301526700003
n3:zamer
n17:MO0FVZ0000501
s:issn
1742-7835
s:numberOfPages
5
n13:doi
10.1111/j.1742-7843.2011.00808.x
n11:organizacniJednotka
G44