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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F11%3A00002580%21RIV12-MO0-G44_____
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://www.biomed.cas.cz/physiolres/pdf/60/60_667.pdf
dcterms:description
Cellular response to ionizing radiation-induced damage depends on the cell type and the ability to repair DNA damage. Some types of cells undergo apoptosis, whereas others induce a permanent cell cycle arrest and do not proliferate. Our study demonstrates two types of response of embryonic diploid fibroblasts WI-38 to ionizing radiation. In the WI-38 cells p53 is activated, protein p21 increases, but the cells are arrested in G2 phase of cell cycle. Some of the cells die by apoptosis, but in remaining viable cells p16 increases, senescence associated DNA damage foci occur, and senescence-associated beta-galactosidase activity increases, which indicate stress-induced premature senescence. Cellular response to ionizing radiation-induced damage depends on the cell type and the ability to repair DNA damage. Some types of cells undergo apoptosis, whereas others induce a permanent cell cycle arrest and do not proliferate. Our study demonstrates two types of response of embryonic diploid fibroblasts WI-38 to ionizing radiation. In the WI-38 cells p53 is activated, protein p21 increases, but the cells are arrested in G2 phase of cell cycle. Some of the cells die by apoptosis, but in remaining viable cells p16 increases, senescence associated DNA damage foci occur, and senescence-associated beta-galactosidase activity increases, which indicate stress-induced premature senescence.
dcterms:title
DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence
skos:prefLabel
DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence
skos:notation
RIV/60162694:G44__/11:00002580!RIV12-MO0-G44_____
n3:aktivita
n19:V n19:P
n3:aktivity
P(GA304/09/1568), V
n3:cisloPeriodika
4
n3:dodaniDat
n14:2012
n3:domaciTvurceVysledku
n15:5470110
n3:druhVysledku
n6:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
195094
n3:idVysledku
RIV/60162694:G44__/11:00002580
n3:jazykVysledku
n4:eng
n3:klicovaSlova
DNA damage; Ionizing radiation; Senescence; Stem cells
n3:klicoveSlovo
n9:Senescence n9:DNA%20damage n9:Ionizing%20radiation n9:Stem%20cells
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[144E41054419]
n3:nazevZdroje
Physiological Research
n3:obor
n8:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:projekt
n18:GA304%2F09%2F1568
n3:rokUplatneniVysledku
n14:2011
n3:svazekPeriodika
60
n3:tvurceVysledku
Kohlerová, Renata Havelek, Radim Cmielová, Jana Seifrtová, Martina Jiroutová, Alena Muthná, Darina Vávrová, Jiřina Řezáčová, Martina
n3:wos
000295057100009
s:issn
0862-8408
s:numberOfPages
11
n16:organizacniJednotka
G44