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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F11%3A00002563%21RIV12-MO0-G44_____
rdf:type
n17:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1093/carcin/bgq213
dcterms:description
We studied the relationship between DNA damage, DNA repair rates and mRNA expression levels of DNA repair genes XRCC1, hOGG1 and XPC in a group of 71 styrene-exposed workers and 51 control individuals. The exposure was assessed by measuring the concentration of styrene in ambient air and in blood. Parameters of DNA damage (measured as single-strand breaks) and DNA repair rates were analyzed in peripheral blood lymphocytes in both groups. A significantly negative correlation was recorded between the DNA damage and styrene concentration at the workplace (r=-0.38, p=0.0001, Pearson). The DNA repair rates were two-fold higher in the exposed group than in the controls (p=0.027; Mann-Whitney U-test). Using the pooled data (the present study and that published by us previously, comprising 113 exposed and 61 control individuals), the DNA repair rates were consistently significantly higher in the exposed group as compared to controls (p=0.0001; Mann-Whitney U-test). mRNA expression levels of XRCC1, hOGG1 and XPC genes were lower in the exposed groups as compared to the controls (p<0.0001; Mann-Whitney U-test). Expression levels of XRCC1, hOGG1 and XPC genes significantly correlated with styrene concentration in blood, a marker of internal exposure (r=-0.66, r=-0.36, and r=-0.40, p=0.0001, respectively; Pearson).Present results provide the evidence on the inverse relationship between DNA damage and DNA repair rates, with further indications of possible DNA repair induction in styrene-exposed subjects. We did not observe any induction of gene expression in the studied DNA repair genes. We studied the relationship between DNA damage, DNA repair rates and mRNA expression levels of DNA repair genes XRCC1, hOGG1 and XPC in a group of 71 styrene-exposed workers and 51 control individuals. The exposure was assessed by measuring the concentration of styrene in ambient air and in blood. Parameters of DNA damage (measured as single-strand breaks) and DNA repair rates were analyzed in peripheral blood lymphocytes in both groups. A significantly negative correlation was recorded between the DNA damage and styrene concentration at the workplace (r=-0.38, p=0.0001, Pearson). The DNA repair rates were two-fold higher in the exposed group than in the controls (p=0.027; Mann-Whitney U-test). Using the pooled data (the present study and that published by us previously, comprising 113 exposed and 61 control individuals), the DNA repair rates were consistently significantly higher in the exposed group as compared to controls (p=0.0001; Mann-Whitney U-test). mRNA expression levels of XRCC1, hOGG1 and XPC genes were lower in the exposed groups as compared to the controls (p<0.0001; Mann-Whitney U-test). Expression levels of XRCC1, hOGG1 and XPC genes significantly correlated with styrene concentration in blood, a marker of internal exposure (r=-0.66, r=-0.36, and r=-0.40, p=0.0001, respectively; Pearson).Present results provide the evidence on the inverse relationship between DNA damage and DNA repair rates, with further indications of possible DNA repair induction in styrene-exposed subjects. We did not observe any induction of gene expression in the studied DNA repair genes.
dcterms:title
DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes
skos:prefLabel
DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes
skos:notation
RIV/60162694:G44__/11:00002563!RIV12-MO0-G44_____
n3:aktivita
n5:I n5:P n5:V n5:Z
n3:aktivity
I, P(GA310/07/1430), P(IAA500390806), V, Z(AV0Z50390512)
n3:cisloPeriodika
1
n3:dodaniDat
n15:2012
n3:domaciTvurceVysledku
n6:6654347
n3:druhVysledku
n4:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
195095
n3:idVysledku
RIV/60162694:G44__/11:00002563
n3:jazykVysledku
n11:eng
n3:klicovaSlova
styrene exposure; genotoxicity; DNA repair; DNA repair rates; gene expression styrene exposure, genotoxicity, DNA repair, DNA repair rates, gene expression, styrene exposure, genotoxicity, DNA repair, DNA repair rates, gene expression, styrene exposure, genotoxicity, DNA repair, DNA repair rates, gene expression,
n3:klicoveSlovo
n7:genotoxicity n7:DNA%20repair n7:gene%20expression%20styrene%20exposure n7:DNA%20repair%20rates n7:gene%20expression n7:styrene%20exposure
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[695B43F61511]
n3:nazevZdroje
Carcinogenesis
n3:obor
n13:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
12
n3:projekt
n10:GA310%2F07%2F1430 n10:IAA500390806
n3:rokUplatneniVysledku
n15:2011
n3:svazekPeriodika
32
n3:tvurceVysledku
Vodičková, Ludmila Slyšková, Jana Lipská, Ludmila Vodička, Pavel Hemminki, Kari Kumar, Rajiv Hanová, Monika Polaková, Veronika Hlaváč, Pavel Naccarati, Alessio Štětina, Rudolf Šmerhovský, Zdeněk
n3:wos
000286303000012
n3:zamer
n20:AV0Z50390512
s:issn
0143-3334
s:numberOfPages
6
n16:organizacniJednotka
G44