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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F11%3A00002515%21RIV12-MO0-G44_____
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://node.nel.edu/?node_id=12160
dcterms:description
OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder. Symptomatic treatment is available by inhibitors of acetylcholinesterase (AChE) such as rivastigmine, galantamine and donepezil. As huperzine is a promising compound for AD treatment, our study was aimed at evaluating its pertinent implications in oxidative stress. METHODS: Laboratory guinea pigs were exposed to huperzine A at doses of 0, 5, 25, 125 and 625 μg/kg. The animals were observed for cognitive disorders and sacrificed one hour after exposure. Tonic-clonic seizures were noticed, but only in highly dosed animals. Ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), glutathione reductase and glutathione S-transferase were assessed in frontal, temporal and parietal lobes, the cerebellum, liver, spleen and kidney. RESULTS: Only minimal changes in enzymatic markers were recognized. Huperzine was not implicated in oxidative stress enhancement as the TBARS values remained quite stable. Surprisingly, antioxidants accumulated in the examined brain compartments as the FRAP value was significantly elevated following all doses of huperzine. CONCLUSIONS: We discuss the potency of huperzine in enhancing the antioxidant capacity of the central nervous system. Huperzine is probably implicated in more processes than cholinesterase inhibition only. OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder. Symptomatic treatment is available by inhibitors of acetylcholinesterase (AChE) such as rivastigmine, galantamine and donepezil. As huperzine is a promising compound for AD treatment, our study was aimed at evaluating its pertinent implications in oxidative stress. METHODS: Laboratory guinea pigs were exposed to huperzine A at doses of 0, 5, 25, 125 and 625 μg/kg. The animals were observed for cognitive disorders and sacrificed one hour after exposure. Tonic-clonic seizures were noticed, but only in highly dosed animals. Ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), glutathione reductase and glutathione S-transferase were assessed in frontal, temporal and parietal lobes, the cerebellum, liver, spleen and kidney. RESULTS: Only minimal changes in enzymatic markers were recognized. Huperzine was not implicated in oxidative stress enhancement as the TBARS values remained quite stable. Surprisingly, antioxidants accumulated in the examined brain compartments as the FRAP value was significantly elevated following all doses of huperzine. CONCLUSIONS: We discuss the potency of huperzine in enhancing the antioxidant capacity of the central nervous system. Huperzine is probably implicated in more processes than cholinesterase inhibition only.
dcterms:title
Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model
skos:prefLabel
Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model
skos:notation
RIV/60162694:G44__/11:00002515!RIV12-MO0-G44_____
n3:aktivita
n6:Z n6:S
n3:aktivity
S, Z(MSM6215712402)
n3:cisloPeriodika
Suppl. 1
n3:dodaniDat
n7:2012
n3:domaciTvurceVysledku
n4:4641531 n4:3876284 n4:7153082 n4:1022989
n3:druhVysledku
n11:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
203006
n3:idVysledku
RIV/60162694:G44__/11:00002515
n3:jazykVysledku
n15:eng
n3:klicovaSlova
huperzine; alzheimer´s disease; acetylcholinesterase; oxidative stress
n3:klicoveSlovo
n5:huperzine n5:oxidative%20stress n5:acetylcholinesterase n5:alzheimer%C2%B4s%20disease
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[809EA91E2C94]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n14:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n7:2011
n3:svazekPeriodika
32
n3:tvurceVysledku
Pikula, Jiří Hrabinová, Martina Zemek, Filip Banďouchová, Hana Pohanka, Miroslav Drtinová, Lucie
n3:zamer
n16:MSM6215712402
s:issn
0172-780X
s:numberOfPages
6
n17:organizacniJednotka
G44