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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F11%3A00002492%21RIV12-MO0-G44_____
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.3109/14756361003733613
dcterms:description
These experiments were performed on a rat model. The rats were divided into eight groups and consequently exposed to either a saline solution (control), atropine or a combination of atropine and tabun. The reactivation efficacy of the oximes was estimated on the rats exposed to tabun, atropine and a reactivator of AChE. The oximes HI-6, obidoxime, trimedoxime, K203 and KR-22836 were used as representative compounds of commonly available and new AChE reactivators. Besides the positive effect of the administered reactivators on blood AChE activity, the sizable modulation of low molecular weight antioxidant (LMWA) levels was also determined. The LMWA levels in the the animals treated with the oxime reactivators were decreased in comparison with the animals treated by atropine alone. It was found that the levels of LMWA returned to the level found in the control animals when either trimedoxime, K203 or KR-22836 were administered. The principle of oxime reactivator function and a novel insight into AChE activity regulation and oxidative stress is discussed. These experiments were performed on a rat model. The rats were divided into eight groups and consequently exposed to either a saline solution (control), atropine or a combination of atropine and tabun. The reactivation efficacy of the oximes was estimated on the rats exposed to tabun, atropine and a reactivator of AChE. The oximes HI-6, obidoxime, trimedoxime, K203 and KR-22836 were used as representative compounds of commonly available and new AChE reactivators. Besides the positive effect of the administered reactivators on blood AChE activity, the sizable modulation of low molecular weight antioxidant (LMWA) levels was also determined. The LMWA levels in the the animals treated with the oxime reactivators were decreased in comparison with the animals treated by atropine alone. It was found that the levels of LMWA returned to the level found in the control animals when either trimedoxime, K203 or KR-22836 were administered. The principle of oxime reactivator function and a novel insight into AChE activity regulation and oxidative stress is discussed.
dcterms:title
Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators
skos:prefLabel
Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators
skos:notation
RIV/60162694:G44__/11:00002492!RIV12-MO0-G44_____
n4:aktivita
n8:S n8:P
n4:aktivity
P(OVUOFVZ200811), S
n4:cisloPeriodika
1
n4:dodaniDat
n17:2012
n4:domaciTvurceVysledku
n5:2182262 n5:4898737 n5:3876284 n5:6306888 n5:6469922
n4:druhVysledku
n9:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
189868
n4:idVysledku
RIV/60162694:G44__/11:00002492
n4:jazykVysledku
n18:eng
n4:klicovaSlova
Acetylcholinesterase; nerve agent; antioxidant; reactivator; cholinergic antiinflammatory pathway; tabun; oxime
n4:klicoveSlovo
n7:oxime n7:antioxidant n7:reactivator n7:cholinergic%20antiinflammatory%20pathway n7:nerve%20agent n7:Acetylcholinesterase n7:tabun
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[AA5B05D54AE9]
n4:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n4:obor
n19:CE
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
6
n4:projekt
n15:OVUOFVZ200811
n4:rokUplatneniVysledku
n17:2011
n4:svazekPeriodika
26
n4:tvurceVysledku
Pohanka, Miroslav Jung, Young-Sik Žďárová Karasová, Jana Kassa, Jiří Musílek, Kamil Kuča, Kamil
n4:wos
000287044200010
s:issn
1475-6366
s:numberOfPages
5
n13:organizacniJednotka
G44