This HTML5 document contains 58 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n14http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F60162694%3AG44__%2F11%3A00002428%21RIV13-GA0-G44_____/
n13http://localhost/temp/predkladatel/
n15http://linked.opendata.cz/resource/domain/vavai/projekt/
n4http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n19http://linked.opendata.cz/ontology/domain/vavai/
n11http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n16http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n20http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n21http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n9http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F11%3A00002428%21RIV13-GA0-G44_____
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.bmcl.2011.08.042
dcterms:description
Cholinesterase inhibitors are, so far, the only successful strategy for the symptomatic treatment of Alzheimer's disease. Tacrine (THA) is a potent acetylcholinesterase inhibitor that was used in the treatment of Alzheimer's disease for a long time. However, the clinical use of THA was hampered by its low therapeutic index, short half-life and liver toxicity. 7-methoxytacrine (7-MEOTA) is equally pharmacological active compound with lower toxicity compared to THA. In this paper, the synthesis, biological activity and molecular modelling of elimination by-product isolated during synthesis of 7-MEOTA based bis-alkylene linked compound is described. Cholinesterase inhibitors are, so far, the only successful strategy for the symptomatic treatment of Alzheimer's disease. Tacrine (THA) is a potent acetylcholinesterase inhibitor that was used in the treatment of Alzheimer's disease for a long time. However, the clinical use of THA was hampered by its low therapeutic index, short half-life and liver toxicity. 7-methoxytacrine (7-MEOTA) is equally pharmacological active compound with lower toxicity compared to THA. In this paper, the synthesis, biological activity and molecular modelling of elimination by-product isolated during synthesis of 7-MEOTA based bis-alkylene linked compound is described.
dcterms:title
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties
skos:prefLabel
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties
skos:notation
RIV/60162694:G44__/11:00002428!RIV13-GA0-G44_____
n3:aktivita
n20:S n20:P n20:Z
n3:aktivity
P(GAP303/11/1907), S, Z(MSM0021620849)
n3:cisloPeriodika
21
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n4:8581223 n4:6469922 n4:6306888
n3:druhVysledku
n17:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
233871
n3:idVysledku
RIV/60162694:G44__/11:00002428
n3:jazykVysledku
n18:eng
n3:klicovaSlova
inhibition selectivity; molecular modelling; butyrylcholinesterase; Alzheimer disease; acetylcholinesterase; 7-methoxytacrine
n3:klicoveSlovo
n7:7-methoxytacrine n7:butyrylcholinesterase n7:inhibition%20selectivity n7:acetylcholinesterase n7:molecular%20modelling n7:Alzheimer%20disease
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[06A420AD599A]
n3:nazevZdroje
Bioorganic & Medicinal Chemistry Letters
n3:obor
n21:FR
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
11
n3:projekt
n15:GAP303%2F11%2F1907
n3:rokUplatneniVysledku
n9:2011
n3:svazekPeriodika
21
n3:tvurceVysledku
Horová, Anna Opletalová, Veronika Kuča, Kamil Holas, Ondřej Zemek, Filip Hroudová, Jana Fišar, Zdeněk Korábečný, Jan Musílek, Kamil Jung, Young-Sik Nepovimova, Eugenie
n3:wos
000296025900071
n3:zamer
n11:MSM0021620849
s:issn
0960-894X
s:numberOfPages
4
n16:doi
10.1016/j.bmcl.2011.08.042
n13:organizacniJednotka
G44