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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002417%21RIV11-MZ0-G44_____
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Ever since proteomics was proven to be capable of characterizing a large number of differences in both protein quality and quantity, it has been applied in various areas of biomedicine, ranging from the deciphering molecular pathogenesis of diseases to the characterization of novel drug targets and the discovery of potential diagnostic biomarkers. Indeed, the biomarker discovery in human plasma is clearly one of the areas with enormous potential. However, without proper planning and implementation of specific techniques, the efforts and expectations may very easily be hampered. Numerous earlier projects aimed at clinical proteomics, characterized by exaggerated enthusiasm, often underestimated some principal obstacles of plasma biomarker discovery. Consequently, ambiguous and insignificant results soon led to a more critical view in this field. In this article, we critically review the current state of proteomic approaches for biomarker discovery and validation, in order to provide basi Ever since proteomics was proven to be capable of characterizing a large number of differences in both protein quality and quantity, it has been applied in various areas of biomedicine, ranging from the deciphering molecular pathogenesis of diseases to the characterization of novel drug targets and the discovery of potential diagnostic biomarkers. Indeed, the biomarker discovery in human plasma is clearly one of the areas with enormous potential. However, without proper planning and implementation of specific techniques, the efforts and expectations may very easily be hampered. Numerous earlier projects aimed at clinical proteomics, characterized by exaggerated enthusiasm, often underestimated some principal obstacles of plasma biomarker discovery. Consequently, ambiguous and insignificant results soon led to a more critical view in this field. In this article, we critically review the current state of proteomic approaches for biomarker discovery and validation, in order to provide basi
dcterms:title
Application of proteomics in biomarker discovery: a primer for the clinician Application of proteomics in biomarker discovery: a primer for the clinician
skos:prefLabel
Application of proteomics in biomarker discovery: a primer for the clinician Application of proteomics in biomarker discovery: a primer for the clinician
skos:notation
RIV/60162694:G44__/10:00002417!RIV11-MZ0-G44_____
n3:aktivita
n17:S n17:P
n3:aktivity
P(NR9253), S
n3:cisloPeriodika
4
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n6:5799503 n6:9773401 n6:5863163 n6:4600622
n3:druhVysledku
n18:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
247478
n3:idVysledku
RIV/60162694:G44__/10:00002417
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Proteomics * Biomarker * Plasma * Mass spectrometry
n3:klicoveSlovo
n9:Proteomics%20%2A%20Biomarker%20%2A%20Plasma%20%2A%20Mass%20spectrometry
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6CF357553D2D]
n3:nazevZdroje
Physiological Research
n3:obor
n15:FA
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n4:NR9253
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
59
n3:tvurceVysledku
Fučíková, Alena Pudil, Radek Lenčo, Juraj Stulík, Jiří Kacerovský, Marian Tambor, Vojtěch Řeháček, Vít
n3:wos
000282054700002
s:issn
0862-8408
s:numberOfPages
27
n5:organizacniJednotka
G44