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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002398%21RIV11-MSM-G44_____
rdf:type
n14:Vysledek skos:Concept
dcterms:description
In this work we aim to summarize the universality of this compound, its reactivatiom potency when different cholinesterase inhibitors are used. Background: Pralidoxime is considered as a gold standard of acetylcholinesterase reactivators - antidotes used in case of nerve agent poisonings. It is commercially available worldwide since many years back. However, several studies describe this oxime as an old-fashion antidote Methods: Pralidoxime was synthesized at our department. The reactivating efficacy was tested on 10% (w/v) rat brain homogenate that was incubated with appropriate inhibitor for 30 minutes to reach 96% inhibition of AChE. Then, pralidoxime was added for 10 minutes. Measurements were performed at 25 °C, pH 8, and at the concentrations of the AChE reactivators at 10-3 and 10-5 M. The activities of brain AChE were measured by a potentiostatic method. Results: No sufficient reactivation was achieved at the concentration 10-5 M, which is a concentration that is possible to reach after adm In this work we aim to summarize the universality of this compound, its reactivatiom potency when different cholinesterase inhibitors are used. Background: Pralidoxime is considered as a gold standard of acetylcholinesterase reactivators - antidotes used in case of nerve agent poisonings. It is commercially available worldwide since many years back. However, several studies describe this oxime as an old-fashion antidote Methods: Pralidoxime was synthesized at our department. The reactivating efficacy was tested on 10% (w/v) rat brain homogenate that was incubated with appropriate inhibitor for 30 minutes to reach 96% inhibition of AChE. Then, pralidoxime was added for 10 minutes. Measurements were performed at 25 °C, pH 8, and at the concentrations of the AChE reactivators at 10-3 and 10-5 M. The activities of brain AChE were measured by a potentiostatic method. Results: No sufficient reactivation was achieved at the concentration 10-5 M, which is a concentration that is possible to reach after adm
dcterms:title
Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro
skos:prefLabel
Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro Pralidoxime - the gold standard of acetylcholinesterase reactivators - reactivation efficacy in vitro
skos:notation
RIV/60162694:G44__/10:00002398!RIV11-MSM-G44_____
n3:aktivita
n5:P
n3:aktivity
P(ME 865)
n3:cisloPeriodika
9
n3:dodaniDat
n12:2011
n3:domaciTvurceVysledku
n7:4898737 n7:4592174 n7:4641531 n7:3876284 n7:6306888
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
280843
n3:idVysledku
RIV/60162694:G44__/10:00002398
n3:jazykVysledku
n18:eng
n3:klicovaSlova
cholinesterase; reactivator; oxime; inhibitor; pralidoxime
n3:klicoveSlovo
n10:oxime n10:cholinesterase n10:pralidoxime n10:inhibitor n10:reactivator
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[289AEB55EA02]
n3:nazevZdroje
Bratislava Medical Journal-Bratislavske Lekarske Listy
n3:obor
n15:FP
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n4:ME%20865
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
111
n3:tvurceVysledku
Kuča, Kamil Soukup, Ondřej Tobin, G. Hrabinová, Martina Žďárová Karasová, Jana Pohanka, Miroslav
n3:wos
000283482300007
s:issn
0006-9248
s:numberOfPages
3
n13:organizacniJednotka
G44