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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002358%21RIV11-MO0-G44_____
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Trichothecenes are a group of mycotoxins mainly produced by the fungi of Fusarium genus. Consumers are particularly concerned over the toxicity and food safety of trichothecenes and their metabolites from food-producing animals. The metabolism of T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-nivalenol (3-aDON), and 15-acetyldeoxynivalenol (15-aDON) in rodents, swine, ruminants, poultry, and humans are reviewed in this article. Metabolic pathways of these mycotoxins are very different. The major metabolic pathways of T-2 toxin in animals are hydrolysis, hydroxylation, de-epoxidation, and conjugation. After being transformed to HT-2 toxin, it undergoes further hydroxylation at C-3? to yield 3?-hydroxy-HT-2 toxin, which is considered as an activation pathway, whereas transformation from T-2 to T-2 tetraol is an inactivation pathway in animals. The typical metabolites of T-2 toxin in animals are HT-2 toxin, T-2 triol, T-2 tetraol, neosolaniol ( Trichothecenes are a group of mycotoxins mainly produced by the fungi of Fusarium genus. Consumers are particularly concerned over the toxicity and food safety of trichothecenes and their metabolites from food-producing animals. The metabolism of T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-nivalenol (3-aDON), and 15-acetyldeoxynivalenol (15-aDON) in rodents, swine, ruminants, poultry, and humans are reviewed in this article. Metabolic pathways of these mycotoxins are very different. The major metabolic pathways of T-2 toxin in animals are hydrolysis, hydroxylation, de-epoxidation, and conjugation. After being transformed to HT-2 toxin, it undergoes further hydroxylation at C-3? to yield 3?-hydroxy-HT-2 toxin, which is considered as an activation pathway, whereas transformation from T-2 to T-2 tetraol is an inactivation pathway in animals. The typical metabolites of T-2 toxin in animals are HT-2 toxin, T-2 triol, T-2 tetraol, neosolaniol (
dcterms:title
Metabolic pathways of trichothecenes Metabolic pathways of trichothecenes
skos:prefLabel
Metabolic pathways of trichothecenes Metabolic pathways of trichothecenes
skos:notation
RIV/60162694:G44__/10:00002358!RIV11-MO0-G44_____
n3:aktivita
n15:I n15:S
n3:aktivity
I, S
n3:cisloPeriodika
2
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n8:6306888
n3:druhVysledku
n14:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
270557
n3:idVysledku
RIV/60162694:G44__/10:00002358
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Trichothecenes; metabolic pathways; biodegradation; Fusarium; animals; human
n3:klicoveSlovo
n4:Trichothecenes n4:metabolic%20pathways n4:biodegradation n4:Fusarium n4:human n4:animals
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[2797912350CB]
n3:nazevZdroje
Drug Metabolism Reviews
n3:obor
n5:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
42
n3:tvurceVysledku
Dohnal, Vlastimil Kuča, Kamil Huang, Lingli Wu, Qinghua Yuan, Zonghui
n3:wos
000276765900002
s:issn
0360-2532
s:numberOfPages
18
n7:organizacniJednotka
G44