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Statements

Subject Item
n2:RIV%2F60162694%3AG44__%2F10%3A00002334%21RIV11-MO0-G44_____
rdf:type
n16:Vysledek skos:Concept
dcterms:description
The pyridinium oxime therapy for treatment of organophosphate poisoning is a well established, but not sufficient method. Recent trends also focus on prophylaxis as a way of preventing even the entrance of organophosphates into the nervous system. One of the possible prophylactic methods is increasing the concentration of butyrylcholinesterase in the blood with the simultaneous administration of butyrylcholinesterase reactivators, when the enzyme is continuously reactivated by oxime. This article summarizes and sets forth the structural differences between butyrylcholinesterase and acetylcholinesterase, essential for the future design of butyrylcholinesterase reactivators. Butyrylcholinesterase lacks the reactivator aromatic binding pocket found in acetylcholinesterase, which is itself a part of the acetylcholinesterase peripheral anionic site. This difference finally renders the current acetylcholinesterase reactivators, when used in butyrylcholinesterase, non-functional. The pyridinium oxime therapy for treatment of organophosphate poisoning is a well established, but not sufficient method. Recent trends also focus on prophylaxis as a way of preventing even the entrance of organophosphates into the nervous system. One of the possible prophylactic methods is increasing the concentration of butyrylcholinesterase in the blood with the simultaneous administration of butyrylcholinesterase reactivators, when the enzyme is continuously reactivated by oxime. This article summarizes and sets forth the structural differences between butyrylcholinesterase and acetylcholinesterase, essential for the future design of butyrylcholinesterase reactivators. Butyrylcholinesterase lacks the reactivator aromatic binding pocket found in acetylcholinesterase, which is itself a part of the acetylcholinesterase peripheral anionic site. This difference finally renders the current acetylcholinesterase reactivators, when used in butyrylcholinesterase, non-functional.
dcterms:title
Why acetylcholinesterase reactivators dont work in butyrylcholinesterase Why acetylcholinesterase reactivators dont work in butyrylcholinesterase
skos:prefLabel
Why acetylcholinesterase reactivators dont work in butyrylcholinesterase Why acetylcholinesterase reactivators dont work in butyrylcholinesterase
skos:notation
RIV/60162694:G44__/10:00002334!RIV11-MO0-G44_____
n4:aktivita
n8:Z
n4:aktivity
Z(MO0FVZ0000604)
n4:cisloPeriodika
3
n4:dodaniDat
n13:2011
n4:domaciTvurceVysledku
n9:4185137 n9:6306888
n4:druhVysledku
n14:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
298798
n4:idVysledku
RIV/60162694:G44__/10:00002334
n4:jazykVysledku
n15:eng
n4:klicovaSlova
butyrylcholinesterase; acetylcholinesterase; reactivation; pyridinium oximes; reactivator aromatic binding pocket; peripheral anionic site
n4:klicoveSlovo
n11:butyrylcholinesterase n11:reactivation n11:reactivator%20aromatic%20binding%20pocket n11:peripheral%20anionic%20site n11:pyridinium%20oximes n11:acetylcholinesterase
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[687816696A47]
n4:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n4:obor
n12:FP
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
5
n4:rokUplatneniVysledku
n13:2010
n4:svazekPeriodika
25
n4:tvurceVysledku
Kuča, Kamil Koca, J. Wiesner, J. Kriz, Z. Jun, Daniel
n4:wos
000276866900004
n4:zamer
n17:MO0FVZ0000604
s:issn
1475-6366
s:numberOfPages
5
n3:organizacniJednotka
G44